Publications by authors named "Andrei M Stoian"
Article Synopsis
- - mRNA vaccines for SARS-CoV-2 have shown great success, pushing interest in mRNA-based drugs due to their quick production and safety, but their instability and degradation in the body require better delivery systems.
- - Lipid nanoparticles (LNPs) are the best current option for safely delivering mRNA, but they need to be stored at low temperatures, which complicates distribution.
- - Lyophilization (freeze-drying) is a promising method to extend the shelf life of mRNA-LNPs under refrigeration, and recent studies indicate that optimizing this process can maintain the vaccines' effectiveness for over a year.
Background: We have previously demonstrated the significant reliance of pancreatic Cancer Stem Cells (PaCSCs) on mitochondrial oxidative phosphorylation (OXPHOS), which enables versatile substrate utilization, including fatty acids (FAs). Notably, dysregulated lipid scavenging and aberrant FA metabolism are implicated in PDAC progression.
Methods & Results: Our bioinformatics analyses revealed elevated expression of lipid metabolism-related genes in PDAC tissue samples compared to normal tissue samples, which correlated with a stemness signature.