Publications by authors named "Andrei Bancu"
Common bile duct duplications represent exceptionally rare congenital anomalies of the biliary tract. In this case report we document an unusual variant of common bile duct duplication in a 79-year-old man who underwent a pancreaticoduodenectomy for ampullary cancer. The duplication consisted of two unseparated, completely-layered, common bile ducts which originated above the cystic duct junction and terminated prior to the point of insertion into the pancreas, where the two lumens converged into a single duct.
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- This study compares three cytological classification systems (C1-C5, Papanicolaou, and WHO) for evaluating pancreatic neuroendocrine lesions in 73 resections over 12 years at a UK center.
- Results showed that the WHO classification had the highest accuracy in categorizing these lesions, while the Papanicolaou system excelled in differentiating neuroendocrine tumors from more aggressive forms like pancreatic adenocarcinoma.
- Overall, the study suggests that while the WHO system reduces ambiguity in malignancy classification, the Papanicolaou system provides practical management benefits without sacrificing accuracy.
Article Synopsis
- Anti-PD-1 therapy has been newly approved by NICE for adults with recurrent and metastatic head and neck squamous cell carcinomas (HNSCC), highlighting the emerging role of immunotherapy in treating these cancers.
- This study aimed to review PD-L1 testing results from HNSCC cases alongside other tumor types and assess how these findings could be integrated into clinical practice for better biomarker utilization.
- Over five years, PD-L1 testing was performed on 199 cancer cases, revealing that while only a few showed positivity, immunotherapy still led to notable improvements in overall survival for patients with PD-L1 positive tumors.
Article Synopsis
- - Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally, and the study focuses on the decreasing role of alpha-fetoprotein (AFP) as a biomarker compared to imaging studies and new biomarkers.
- - The research involved 131 newly diagnosed HCC patients, analyzing the relationship between elevated AFP levels and various tumor and liver features, using a cut-off level of 200 IU/mL.
- - Results indicated that a tumor size greater than 5 cm is a significant predictor of elevated AFP levels, along with other factors like tumor type and portal vein thrombosis, suggesting that AFP may still be a useful tool in certain contexts, particularly in developing countries.