Lanthanide Coordination Polymers with Soft-Base Ditopic Bisthiazolate Ligands.

In order to prepare the first lanthanide coordination polymers (CPs) based on ditopic sulfide ligands, benzo[1,2-:4,5-']bisthiazole-2,6(3,7)-dithione (HL) was used as a linker. The reactions of lanthanide silylamides Ln[N(SiMe)] (Ln = Nd, Gd, Er, and Yb) with HL result in the formation of soluble dimethyl sulfoxide (DMSO) ionic salts [Ln(DMSO)][L] [Ln = Nd (), Gd (), Er (), and Yb ()]. Due to the lack of coordination of anionic ligands, compounds , , and do not show sensitized metal-centered photoluminescence (PL), while Gd compound shows weak phosphorescence at 77 K.

Optical Properties and Upconversion Luminescence of BaTiO Xerogel Structures Doped with Erbium and Ytterbium.

Erbium upconversion (UC) photoluminescence (PL) from sol-gel derived barium titanate (BaTiO:Er) xerogel structures fabricated on silicon, glass or fused silica substrates has been studied. Under continuous-wave excitation at 980 nm and nanosecond pulsed excitation at 980 and 1540 nm, the fabricated structures demonstrate room temperature PL with several bands at 410, 523, 546, 658, 800 and 830 nm, corresponding to the H → I, H → I, S → I, F→ I and I→ I transitions of Er ions. The intensity of erbium UC PL increases when an additional macroporous layer of strontium titanate is used beneath the BaTiO xerogel layer.

Hyperprolactinemia and Antipsychotic Therapy in Schizophrenic Patients with Hashimoto's Thyroiditis.

Introduction: Hyperprolactinemia (HPRL) is known as a side effect of some antidepressants and antipsychotics. These medicines are common in treatment of schizophrenia. Thus, HPRL is often observed in schizophrenic patients.

Infrared stimulated emission with an ultralow threshold from low-dislocation-density InN films grown on a vicinal GaN substrate.

Near-infrared stimulated emission from a high-quality InN layer under optical pumping was observed with a threshold excitation power density of 0.3 and 4 kW cm at T = 8 and 77 K, respectively. To achieve such a low threshold power density, vicinal GaN substrates were used to reduce the edge-component threading dislocation (ETD) density of the InN film.

Luminescence thermochromism in novel mixed Eu(II)-Cu(I) iodide.

A new mixed Eu(II)-Cu(I) iodide [Eu(DME)][CuI] (1) was synthesized by the reaction of an organosulphide salt of Eu(II) and CuI in DME media. X-ray analysis revealed that 1 is an ate-complex consisting of Eu(DME) dications and tetraiododicuprate dianions. Upon UV light excitation ( = 365 nm), the compound exhibits intense double-peaked photoluminescence (PL) at 445 and 500 nm.

Decreased mRNA levels found in men with substance use disorders.

gene (fragile X mental retardation 1) represents a genetic and epigenetic factor in a number of human diseases. Though the role of gene in substance use disorders (SUDs) is not well studied, a number of investigations indicate that SUDs and -accociated disorders may share common underlying mechanisms. We examined the relative mRNA levels and their sex-distribution in leukocytes from patients with alcohol and drug dependence compared to healthy controls.

A Small Cationic Organo-Copper Cluster as Thermally Robust Highly Photo- and Electroluminescent Material.

Organic light-emitting diodes (OLEDs) are revolutionizing display applications. In this aspect, luminescent complexes of precious metals such as iridium, platinum, or ruthenium still playing a significant role. Emissive compounds of earth-abundant copper with equivalent performance are desired for practical, large-scale applications such as solid-state lighting and displays.

Features of the Molecular Structure and Luminescence of Rare-Earth Metal Complexes with Perfluorinated (Benzothiazolyl)phenolate Ligands.

A set of Sc, Nd, Sm, Eu, Ho, Gd, Er, Yb complexes with perfluorinated 2-(benzothiazol-2-yl)phenolate ligands Ln(SON)(DME) were synthesized by the reactions of silylamides Ln[N(SiMe)] with phenol H(SON). The structure of the initial phenol, Sc, and Er complexes was established using X-ray analysis, which revealed that the obtained compounds are mononuclear, in contrast to the binuclear non-fluorinated analogues [Ln(SON)] synthesized earlier. All the obtained complexes, both in solid state and in tetrahydrofuran (THF) solutions, upon excitation by light with λ 395 or 405 nm show intense luminance of the ligands at 440-470 nm.

Synthesis, structure and long-lived NIR luminescence of lanthanide ate complexes with perfluorinated 2-mercaptobenzothiazole.

To obtain new efficient lanthanide-based NIR luminophores perfluorinated 2-mercaptobenzothiazole was used as a ligand. The ate-complexes [(Ln(mbtF)4)-(Na(DME)3)+] of Nd (1), Sm (2), Tb (3), Er (4), Yb (5) and [(Y(mbtF)4)-(Li(DME)3)+] (6) were synthesized in high yields by the reactions of the respective silylamide compounds Ln[N(SiMe3)2]3 and M[N(SiMe3)2] (M = Li, Na) with 4,5,6,7-tetrafluoro-1,3-benzothiazol-2(3H)-thione (HmbtF) in DME media. The complexes 1-3 and 6 were structurally characterized by X-ray diffraction analysis.

Towards the indium nitride laser: obtaining infrared stimulated emission from planar monocrystalline InN structures.

The observation of a stimulated emission at interband transitions in monocrystalline n-InN layers under optical pumping is reported. The spectral position of the stimulated emission changes over a range of 1.64 to 1.

The combined effect of CYP2D6 and DRD2 Taq1A polymorphisms on the antipsychotics daily doses and hospital stay duration in schizophrenia inpatients (observational naturalistic study).

Background: To assess the correlation between the antipsychotics (AP) mean daily doses, hospital stay duration and CYP2D6, DRD2 polymorphisms in naturalistic study.

Subjects And Methods: CYP2D6 polymorphisms *3, *4, *5, *6, *1XN and DRD2/ANKK1 Taq1A polymorphisms were genotyped in a cohort of 226 Caucasian schizophrenic inpatients. AP daily doses, hospital stay duration and AP treatment duration were taken from medical records.

Sensitization of NIR luminescence of Yb by Zn chromophores in heterometallic complexes with a bridging Schiff-base ligand.

Herein, complexes [ZnL] (1), {(HO)Zn(μ-L)Yb[OCH(CF)]} (2), {[(CF)HCO]Zn(μ-L)Yb[OCH(CF)](μ-OH)} (3), and [(HO)Ln(L)] (Ln = Yb (4) and Gd (5)) containing a bridging Schiff-base ligand (HL = N,N'-bis(3-methoxy salicylidene)phenylene-1,2-diamine) were synthesized. The compounds 1-4 were structurally characterized. The ytterbium derivatives 2-4 exhibited bright NIR metal-centred photoluminescence (PL) of Yb ion under one- (λ = 380 nm) and two-photon (λ = 750 nm) excitation.

LMCT facilitated room temperature phosphorescence and energy transfer in substituted thiophenolates of Gd and Yb.

To obtain luminescent lanthanide complexes with a low energy LMCT state the 2-(2'-mercaptophenyl)benzothiazolates, Ln(SSN), and 2-(2'-mercaptophenyl)benzoxazolates, Ln(OSN) (Ln = Gd, Yb), were synthesized by the reaction of amides Ln[N(SiMe)] with respective thiophenols. Ytterbium complexes were structurally characterized by X-ray diffraction analysis. Cyclic voltammetry revealed that the deprotonated mercaptophenyl ligands have significantly lower oxidation potentials than their phenoxy analogues and some β-diketones.

Features of spectral properties of Sm(3+) complexes with dithia- and diselenophosphinate ligands.

The samarium complexes Sm(S2PPh2)3(THF)2 (1) and Sm(Se2PPh2)3(THF)2 (2) with soft-donor dithia- and diselenophosphinate ligands were synthesized and their photophysical properties were studied in detail. Both complexes displayed the metal-centered photoluminescence (PL) in visible and NIR regions corresponding to (4)G5/2→(6)HJ (J=5/2, 7/2, 9/2, 11/2, 13/2, 15/2), (6)FJ (J=1/2, 3/2, 5/2, 7/2, 9/2, 11/2) f-f transitions of Sm(3+). Luminescence decay curves exhibit an initial short build-up region and can be described by double or triple exponential function owing to multiphonon relaxation from the (4)F3/2 energy level to the (4)G5/2 one and reversible energy transfer from the Sm(3+) excited states to the triplet ((3)T1) state of phosphinate ligand.

Luminescent properties of 2-mercaptobenzothiazolates of trivalent lanthanides.

A series of lanthanide complexes (Ln = Nd, Sm, Eu, Gd and Yb) with anionic 2-mercaptobenothiazolate (mbt) ligands were synthesized. Depending on the solvents chosen for the synthesis, Ln(mbt)3(THF)2 and Ln(mbt)3(Et2O) complexes were precipitated from THF and Et2O solutions respectively. The structure of Yb(mbt)3(Et2O) was determined by X-ray analysis.

[The use of mGlu2/3 receptors as a new approach to treat schizophrenia: results of a randomized double-blind trial].

Glutamate neurotransmission has been considered as one of pathogenetic factors of schizophrenia though all antipsychotics widely used in modern psychiatric practice are dopamine antagonists. LY2140023 is a selective agonist for metabotropic glutamate 2/3 (mGlu2/3) receptors with antipsychotic effect. In the present study, we have assessed clinical efficacy of LY2140023 in patients with schizophrenia compared to the control group receiving olanzapine in a randomized double-blind placebo-controlled trial.

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.

Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. These pathological features manifest behaviorally as positive symptoms (including hallucinations, delusions and thought disorder), negative symptoms (such as social withdrawal, apathy and emotional blunting) and other psychopathological symptoms (such as psychomotor retardation, lack of insight, poor attention and impulse control). Altered glutamate neurotransmission has for decades been linked to schizophrenia, but all commonly prescribed antipsychotics act on dopamine receptors.

[The effect of GABA-positive agents on the formation of morphine dependence and on the manifestations of a withdrawal syndrome].

Experiments on mice showed that the GABA-positive preparations (THIP, baclofen, fenibut, valproate sodium) intraperitoneally injected in the course of the morphine addiction development (double daily subcutaneous injections at a dose increasing from 10 to 100 mg/kg over a period of 8 days) and, to a greater extent, upon cessation of the morphine injections, partly reduce manifestations of the naloxone-enhanced (0.1 mg/kg, s.c.

[Regulation of the mouse aggressive behavior (pharmacologic analysis of the GABAergic mechanism)].

Ethological procedures were used to study the effects of GABA-positive drugs on aggression in male albino mice kept in isolation (opponent test). The results revealed several variants of antiaggressive effects of the tested GAB Aergic drugs: 1) antiaggressive, re-socializing of GABAA agonists muscimol (0.125 and 0.

[A pharmaco-ethological study of the GABA-ergic mechanisms regulating the depression-like behavior of mice].

It is known that repeated stress may result in depression-like alterations of behavior. This behavior is characterized by decreased social exploratory activity and increase in occurrence of defensive postures in a social interaction test in mice. The passive defensive behavior is effectively antagonized by antidepressant drugs thus providing a useful animal model of depression.

[Role of the GABA system in adaptation to long-term pain stimulation].

Pain syndrome induced by daily peritoneal electrostimulation in rats within two weeks caused decrease in body weight and in motor behavior in open-field test. Moreover, there were a decrease in thymus weight, an increase in adrenal weight and an appearance in most of animals of gastric mucosal erosions. The disturbances of the behavior and somatic state of animals are accompanied by changes of GABA and energy metabolism in the neurons of the frontal cortex.

[Study of pain sensitivity based on the indicators of electro- odontometry in patients with depersonalization and depressive disorders].

Electroodontometry was used to examine the pain threshold and sensation threshold in patients with depersonalization, endogenous depression and in mentally healthy test subjects. The strongest differences in the thresholds were found on the anterior teeth. The patients with depersonalization manifested a considerable rise of the sensation threshold and to an ever greater degree of the pain threshold.

[The effect of pain caused by multiple trauma on gamma-aminobutyric acid metabolism and the functional condition of animals].

Multiple injury to the bone tissue in rats caused changes of gamma-aminobutyric acid (GABA) metabolism manifested first by activation of its synthesis and then by inhibition of enzymatic inactivation and increase in GABA content in the brain. The initial reaction of the GABA system was attended by a loss of total body and thymus weight, increase in adrenal weight, and bicocculin- and picrotoxin-sensitive hypoalgesia in the tail-flick test. The subsequent changes of GABA-ergic transmission developed during restoration of the animals' functional condition but body weight loss persisted.