Publications by authors named "Andreea Iulia Vladulescu-Trandafir"
: A degenerative joint disease that primarily affects elderly individuals, osteoarthritis (OA) causes pain, decreased mobility, and a lower quality of life. Procaine is regarded as a "veteran" medicine due to its extensive clinical use, although it remains a molecule of interest, as researchers are uncovering new biological and pharmacological effects through innovative experimental methods. This study evaluates the efficacy of the "procaine complex", developed in our country, in alleviating pain and improving functionality in elderly individuals with osteoarthritis of the knee and hip.
View Article and Find Full Text PDFRecent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through the microbiota-gut-brain axis, including in Alzheimer's disease (AD). This review aims to provide a comprehensive synthesis of recent findings on the involvement of gut and oral microbiota in the neuroinflammatory processes associated with AD, emphasizing novel insights and therapeutic implications. This review reveals that dysbiosis in AD patients' gut and oral microbiota is linked to heightened peripheral and central inflammatory responses.
View Article and Find Full Text PDFArticle Synopsis
- Rheumatoid arthritis (RA) patients experience unique challenges when infected with SARS-CoV-2 due to their immunocompromised status and treatments, which complicates their health outcomes compared to the general population.
- The systematic review, adhering to PRISMA guidelines, analyzed literature from 2021-2023 and highlighted issues such as delays in treatment due to COVID-19 fears and increased risk of severe outcomes tied to cardiovascular and metabolic conditions.
- Additionally, the review found that while COVID-19 vaccines are generally safe for RA patients, certain treatments like Methotrexate and Rituximab may weaken their vaccine response, emphasizing the need for tailored medical management during the pandemic.
Signaling Paradigms of HS-Induced Vasodilation: A Comprehensive Review.
Antioxidants (Basel)
September 2024
Article Synopsis
- * HS promotes vasodilation mainly by activating ATP-sensitive potassium channels and inhibiting L-type calcium channels, leading to more relaxed vascular smooth muscle cells and increased blood flow.
- * The gas also boosts the effects of cyclic guanosine monophosphate (cGMP) through the stimulation of soluble guanylyl cyclase and enhances nitric oxide availability, creating a synergistic effect that further supports blood vessel relaxation.
Background: Rheumatoid arthritis (RA) patients are at heightened risk of Coronavirus Disease-19 (COVID-19) complications due to immune dysregulation, chronic inflammation, and treatment with immunosuppressive therapies. This study aims to characterize the clinical and laboratory parameters of RA patients diagnosed with COVID-19, identify predictive risk factors for severe forms of this infection for RA patients, and determine if any RA immunosuppressive therapy is associated with worse COVID-19 outcomes.
Methods: A retrospective observational case-control study included 86 cases (43 diagnosed with RA and 43 cases without any inflammatory or autoimmune disease) that suffered from SARS-CoV-2 in two Romanian hospitals between March 2020 and February 2024.