Publications by authors named "Andree-Anne Marotte"
J Alzheimers Dis
March 2024
Article Synopsis
- Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are neurodegenerative diseases characterized by tau pathology, where AD leads to cognitive decline and PSP affects movement and balance; Progranulin (PGRN) is relevant to both conditions and can be targeted by AZP2006, a synthetic compound aimed at stabilizing PGRN and reducing tau aggregation.
- A phase 1 clinical study evaluated AZP2006's safety, tolerability, and pharmacokinetics involving healthy male volunteers receiving various doses; no severe adverse events occurred, and any minor side effects were temporary.
- AZP2006 was quickly absorbed and had a favorable safety profile, but elevated levels of its M2 metabolite require further
