Publications by authors named "Andreas-Christian Hade"
Currently available clinical treatments on alcohol use disorder (AUD) exhibit limited efficacy and new druggable targets are required. One promising approach to discover new molecular treatment targets involves the transcriptomic profiling of brain regions within the addiction neurocircuitry, utilizing animal models and postmortem brain tissue from deceased patients with AUD. Unfortunately, such studies suffer from large heterogeneity and small sample sizes.
View Article and Find Full Text PDFBackground: Chemical fixation of the brain can be executed through either the immersion method or the perfusion method. Perfusion fixation allows for better preservation of the brain tissue's ultrastructure, as it provides rapid and uniform delivery of the fixative to the tissue. Still, not all facilities have the expertise to perform perfusion fixation, with initial high cost and complexity of perfusion systems as the main factors limiting its widespread usage.
View Article and Find Full Text PDFArticle Synopsis
- The Mediodorsal (MD) thalamus plays a crucial role in brain relay systems and has been overlooked in research on alcohol use disorder (AUD).
- A study analyzed MD thalamic regions from AUD subjects and controls, revealing significant upregulation of 2802 transcripts and downregulation of 1893 genes in those with AUD.
- Key findings included increased expression of genes related to glutamate and GABA neurotransmission, while immune system-related genes were often downregulated, highlighting major molecular changes in the MD thalamus due to long-term alcohol use.