Publications by authors named "Andreas Ziebart"
Background: Decompressive craniectomy (DC) can alleviate increased intracranial pressure in aneurysmal subarachnoid hemorrhage patients with concomitant space-occupying intracerebral hemorrhage, but also carries a high risk for complications. We studied outcomes and complications of DC at time of ruptured aneurysm repair.
Methods: Of 47 patients treated between 2010 and 2020, 30 underwent DC during aneurysm repair and hematoma evacuation and 17 did not.
Article Synopsis
- A study looked at how well people are doing after having a serious brain bleed called spontaneous subarachnoid hemorrhage from 1973 to 2017.
- They found that fewer people were dying from this condition over the years, but the improvement has stalled recently.
- The results about how many people could live independently were unclear, showing only a slight increase in the last few decades.
Background And Objective: No study on neurostimulation in narcolepsy is available until now. Arousal- and wake-promoting effects of vagus nerve stimulation (VNS) have been demonstrated in animal experiments and are well-known as side effects of VNS therapy in epilepsy and depression. The objective was to evaluate the therapeutic effect of VNS on daily sleepiness and cataplexies in narcolepsy.
View Article and Find Full Text PDFIntroduction: Vagus nerve stimulation (VNS) is an effective, non-pharmacological therapy for epileptic seizures. Until now, favorable combinations of different groups of antiseizure medication (ASM) and VNS have not been sufficiently addressed. The aim of this study was to identify the synergistic effects between VNS and different ASMs.
View Article and Find Full Text PDFObjective: The subarachnoid haemorrhage (SAH) outcome tool (SAHOT) is the first SAH-specific patient reported outcome measure, and was developed in the UK. We aimed to validate the SAHOT outside the UK, and therefore endeavored to adapt the SAHOT into German and to test its psychometric properties.
Methods: We adapted and pilot tested the German version.
Background: Reliable on site classification of resected tumor specimens remains a challenge. Implementation of high-resolution confocal laser endoscopic techniques (CLEs) during fluorescence-guided brain tumor surgery is a new tool for intraoperative tumor tissue visualization. To overcome observer dependent errors, we aimed to predict tumor type by applying a deep learning model to image data obtained by CLE.
View Article and Find Full Text PDFArticle Synopsis
- Regulatory B cells (B) in the tumor microenvironment produce adenosine (ADO), which suppresses T cell function, but their self-regulatory effects and role in head and neck cancer need further exploration.
- Blood and tumor samples from cancer patients and healthy donors were analyzed to understand how ADO affects B cells' signaling and function, and a mouse model was used to study ADO receptors' impact on tumor growth.
- The study found that ADO-producing B cells exist in tumors and inhibit key signaling pathways, suggesting that targeting the ADO pathway in B cells could offer new therapeutic strategies for cancer treatment.
Introduction: Head and neck squamous cell carcinoma (HNSCC) strongly suppresses the immune system, resulting in increased metastasis and recurrent disease. Chemotherapy is part of the multimodal treatment but may further immunosuppression. Recently, we demonstrated that regulatory B cells (Breg), defined as CD19CD39CD73 B cells, play a significant role in the production of immunosuppressive, extracellular adenosine (ADO).
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