Publications by authors named "Andreas T Hagen"
Article Synopsis
- The mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 proteins allows cells to avoid death from DNA damage, a hurdle in cancer development and treatment resistance.
- Depleting or inhibiting checkpoint kinase 1 (Chk1) in zebrafish embryos restores the ability to undergo apoptosis in response to gamma radiation, but through a different mechanism that does not rely on the usual activation of caspase-3.
- This alternative apoptosis pathway, dependent on ATM, ATR, and caspase-2, operates independently of p53 mutations or Bcl-2 overexpression, suggesting potential new targets for cancer therapies involving Chk1 inhibitors.
