VPMBench: a test bench for variant prioritization methods.

Background: Clinical diagnostics of whole-exome and whole-genome sequencing data requires geneticists to consider thousands of genetic variants for each patient. Various variant prioritization methods have been developed over the last years to aid clinicians in identifying variants that are likely disease-causing. Each time a new method is developed, its effectiveness must be evaluated and compared to other approaches based on the most recently available evaluation data.

PROVenance Patterns in Numerical Modelling and Finite Element Simulation Processes of Bio-electric Systems.

The reproducibility of scientific results gains increasing attention. In the context of biomedical engineering, this applies to experimental studies of three different kinds: in-vivo, in-vitro, and in-silico. Numerical modelling and finite element simulation of bio-electric systems are intricate processes involving manifold steps.