Development and technical validation of an ultrasound nebulizer to deliver intraperitoneal pressurized aerosols in a rat colon cancer peritoneal metastases model.

Background/aim: To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model.

Material And Methods: For aerosol generation, an ultrasonic nebulizer (USN) was modified. Aerosol analyses were performed ex-vivo by laser diffraction spectrometry (LDS).

Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis.

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models.

Experimental Model to Test Electrostatic Precipitation Technology in the COVID-19 Era: A Pilot Study.

Background: In the COVID-19 crisis, laparoscopic surgery is in focus as a relevant source of bioaerosol release. The efficacy of electrostatic aerosol precipitation (EAP) and continuous aerosol evacuation (CAE) to eliminate bioaerosols during laparoscopic surgery was verified.

Study Design: Ex-vivo laparoscopic cholecystectomies (LCs) were simulated ± EAP or CAE in Pelvitrainer equipped with swine gallbladders.

Surface Modification of Biodegradable Polymers towards Better Biocompatibility and Lower Thrombogenicity.

Purpose: Drug-eluting stents (DES) based on permanent polymeric coating matrices have been introduced to overcome the in stent restenosis associated with bare metal stents (BMS). A further step was the development of DES with biodegradable polymeric coatings to address the risk of thrombosis associated with first-generation DES. In this study we evaluate the biocompatibility of biodegradable polymer materials for their potential use as coating matrices for DES or as materials for fully bioabsorbable vascular stents.

Collaborative network of predictive markers complicates formation of prognostic groups in patients with advanced lung cancer.

Background: Evaluation of cancer therapies is mainly based on prolonging remission status and effect of survival. Various serological, clinical or histological markers are used to estimate the patient's prognosis, and to tailor specific therapies for patients with poor prognosis. However, it is still a challenge to combine all this information into a comprehensive risk prediction.

Bacterial colonization of psoriasis plaques. Is it relevant?

Bacterial colonization was investigated retrospectively in patients with plaque psoriasis (n=98 inpatient treatments, n=73 patients). At least one pathogen was found in 46% of all cases. Staphylococcus aureus was the most frequent bacterium.

Position controlled self-catalyzed growth of GaAs nanowires by molecular beam epitaxy.

GaAs nanowires are grown by molecular beam epitaxy using a self-catalyzed, Ga-assisted growth technique. Position control is achieved by nano-patterning a SiO(2) layer with arrays of holes with a hole diameter of 85 nm and a hole pitch varying between 200 nm and 2 µm. Gallium droplets form preferentially at the etched holes acting as catalyst for the nanowire growth.

Ferromagnetic GaAs/GaMnAs core-shell nanowires grown by molecular beam epitaxy.

GaAs/GaMnAs core-shell nanowires were grown by molecular beam epitaxy. The core GaAs nanowires were synthesized under typical nanowire growth conditions using gold as catalyst. For the GaMnAs shell the temperature was drastically reduced to achieve low-temperature growth conditions known to be crucial for high-quality GaMnAs.

Influence of nonhomogeneous distribution of topically applied UV filters on sun protection factors.

The aim of the present study is the development of a method to determine quantitatively in vivo the influence of homogeneity of the distribution of sunscreen containing UV filters on the sun protection factor (SPF). The SPF of a sunscreen applied either topically or inside an optical cell (pure or in a solvent) fixed above the skin is determined in vivo. In both cases, in vivo measurements using the erythema formation are carried out.