Publications by authors named "Andreas Rosskopf"
Background And Objectives: Differentiation of lipomatous tumors mostly requires diagnostic biopsy but is essential to decide for the most adequate therapy. This study aims to investigate the prognostic value of available clinical and radiological features with regard to malignancy of the lesion, recurrence and survival.
Methods: In this retrospective cohort study, 104 patients with a biopsy-proven lipomatous tumor between 2010 and 2015 and a minimum clinical follow-up of two years were enrolled.
Purpose: To evaluate the distribution and severity of muscle atrophy in diabetic patients with active Charcot foot (CF) compared to diabetic patients without CF. Furthermore, to correlate the muscle atrophy with severity of CF disease.
Material/methods: In this retrospective study, MR images of 35 diabetic patients (21 male, median:62.
Objective: To develop a new magnetic resonance imaging(MRI) scoring system for evaluation of active Charcot foot and to correlate the score with a duration of off-loading treatment ≥ 90 days.
Methods: An outpatient clinic database was searched retrospectively for MRIs of patients with active Charcot foot who completed off-loading treatment. Images were assessed by two radiologists (readers 1 and 2) and an orthopedic surgeon (reader 3).
Charcot foot refers to an inflammatory pedal disease based on polyneuropathy; the detailed pathomechanism of the disease is still unclear. Since the most common cause of polyneuropathy in industrialized countries is diabetes mellitus, the prevalence in this risk group is very high, up to 35%. Patients with Charcot foot typically present in their fifties or sixties and most of them have had diabetes mellitus for at least 10 years.
View Article and Find Full Text PDFObjective: To test a 3D-hindfoot alignment (HA) measurement technique based on low-dose biplanar radiographs (BPRs) in a clinical setting and compare the results with 2D-HA measurements on long axial view radiographs (LARs).
Materials And Methods: This prospective study was approved by the local institutional review board. HA measurements on 3D-BPR and 2D-LAR of 50 patients (29 female; mean age 47 ± 16.
Objective: To assess whether the use of cartilaginous contours at the femoral condyles instead of bony contours significantly changes femoral torsion measurements in children.
Materials And Methods: Femoral torsion was measured in 32 girls (mean age 10.1 years±2.
Objective: The aim of our study was to evaluate the reliability and interchangeability of femoral (FT) and tibial torsion (TT) measurements in children using magnetic resonance (MR) imaging compared to measurements on 3D models based on biplanar radiographs (BPR).
Materials And Methods: FT and TT were measured in 60 children (mean age 10.1 years; range 6.
Objective: The purpose of this study is to compare the reliability of SW velocity measurements of two different ultrasound systems and their correlation with the tangent traction modulus in a non-static tendon strain model.
Materials And Methods: A bovine tendon was fixed in a custom-made stretching device. Force was applied increasing from 0 up to 18 Newton.
Objective: To evaluate reliability of 2D and 3D lower limb measurements in adults using micro-dose compared to low-dose biplanar radiographs(BPR).
Materials And Methods: One hundred patients (mean 54.9 years) were examined twice using micro-dose and low-dose BPR.
Objective: To compare detection of spinal ligament enthesitis between gadolinium-enhanced fat-saturated T1-weighted gadolinium-enhanced fat-saturated T1-weighted (T1+Gd) and STIR sequences in patients with suspected spondyloarthritis.
Materials And Methods: Sixty-eight patients (37 males, 42 ± 14 years) with a sacroiliac-joint (SIJ) and lumbar spine MRI for suspected spondyloarthritis were prospectively included. Sagittal T1+Gd and STIR images of the lumbar spine were assessed by two readers for enthesitis of interspinous/supraspinous ligaments, and for capsulitis of facet-joints between T12-S1.
Unlabelled: Specimen collection method and quality insurance are pivotal in biomarker discovery. Pre-analytical variables concerning blood collection and sample handling might affect analytical results and should be standardised prior application. In this study, we examine pre-analytical characteristics of blood samples using protein microarray.
View Article and Find Full Text PDFThe T-allele in the GNB3 C825T polymorphism has been associated with increased cell migration, a prerequisite for metastasis. In this study we investigated a potential association of the C825T-allele status and disease progression in patients with transitional cell carcinoma of the bladder (TCC). Genotyping of the GNB3 C825T polymorphism was performed in 389 patients with transitional cell carcinoma of the bladder and in 104 control subjects and clinical follow-up was worked up in 339 patients.
View Article and Find Full Text PDFObjective: Recent analysis gave evidence for the fact that the chemokine receptor CXCR4 is of functional significance in the multistep procedure of metastasis directing tumor cells to their metastatic target organs. In our study we investigated the expression of the CXCR4 receptor on bladder cancer cells and the functional activation of the CXCR4 receptor in bladder cancer cell lines regarding signal transduction pathways, which are involved in metastasis.
Methods: Receptor transcript expression was analysed and quantified by reverse transcription PCR with RNA extracted from different samples of native human bladder cancer tissue, normal urothelium and the bladder cancer cell lines J82 and T24.