Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy.

Purpose: Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).

Long term effect of trabeculectomy on retrobulbar haemodynamics in glaucoma.

Purpose: Previous reports showed increased flow velocities in retrobulbar vessels after glaucoma surgery in the first weeks. Colour Doppler imaging was performed to investigate the long-term effects of trabeculectomy on retrobulbar haemodynamics in patients with primary open-angle glaucoma (POAG).

Methods: In a prospective study 30 patients (mean age 63.

Arteriovenous passage times and visual field progression in normal tension glaucoma.

Purpose: Fluorescein angiographic studies revealed prolonged arteriovenous passage (AVP) times and increased fluorescein filling defects in normal tension glaucoma (NTG) compared to healthy controls. The purpose of this study was to correlate baseline AVP and fluorescein filling defects with visual field progression in patients with NTG.

Patients And Methods: Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study.

Retrobulbar blood flow and visual field alterations after acute ethanol ingestion.

Background: The purpose of this study was to test the effect of ethyl alcohol on the koniocellular and magnocellular pathway of visual function and to investigate the relationship between such visual field changes and retrobulbar blood flow in healthy subjects.

Methods: In 12 healthy subjects (mean age 32 ± 4 years), color Doppler imaging, short-wavelength automated perimetry, and frequency doubling perimetry was performed before and 60 minutes after oral intake of 80 mL of 40 vol% ethanol. Mean and pattern standard deviations for short-wavelength automated and frequency doubling perimetry were assessed.

Tonometry in corneal edema after cataract surgery: dynamic contour tonometry versus Goldmann applanation tonometry.

Introduction: Intraocular pressure (IOP) determination using dynamic contour tonometry (DCT) has been considered to be independent of central corneal thickness (CCT), while Goldmann applanation tonometry (GAT) is known to be influenced by various corneal properties. In this study, IOP was measured before and 1 day after cataract surgery using GAT and DCT to investigate the possible effects of corneal edema on IOP measurements.

Methods: Thirty patients with advanced cataracts were included in a pilot study.

Retrobulbar hemodynamics before and after oculopression with and without dorzolamide.

Purpose: To investigate the effect of intraocular pressure (IOP) reduction by oculopression and topical dorzolamide on retrobulbar hemodynamics.

Methods: Sixty patients (70 ± 8.5) solely with cataract diagnosis solely were included in this prospective study.

Optic disc fluorescein leakage and intraocular pressure in primary open-angle glaucoma.

Purpose: To investigate the relationship between increased fluorescein leakage of the optic nerve head and intraocular pressure (IOP), visual field defect, vertical cup-to-disc ratio, disc size and systemic blood pressure in primary open-angle glaucoma (POAG).

Methods: Twenty-seven patients with POAG (aged 63 ± 11 years) and 15 control subjects (aged 58 ± 9 years, p = 0.14) were included in a pilot study.

Ocular pulse amplitude before and after cataract surgery.

Purpose: To investigate the impact of cataract surgery on the association of the ocular pulse amplitude (OPA) and intraocular pressure (IOP) with respect to the interpretation of OPA as an estimate of ocular blood flow.

Methods: Twenty-four patients with cataract were included in a clinical study. OPA was measured using dynamic contour tonometry (DCT, Pascal(®), SMT Swiss Microtechnology AG, Switzerland).

Fluorescein leakage of the optic disc: time course in primary open-angle glaucoma.

Purpose: To identify and quantify the time course of fluorescein leakage of the optic nerve head in primary open-angle glaucoma (POAG) and controls.

Methods: Twenty patients with POAG (aged 58 +/- 10 years) and 14 controls (aged 51 +/- 12 years, p = 0.07) were included in a prospective study.

New treatment option for adult-onset limbal xanthogranuloma.

Purpose: The purposes of this study are to report a case of adult-onset juvenile xanthogranuloma and suggest a new treatment option.

Methods: A 35-year-old man presented with an isolated mass of the limbus. Biopsy revealed a histiocytic tumor with Touton's giant cells staining positive for CD68 and S-100 but negative for CD1a, consistent with JXG.

Recurrent suprachoroidal dislocation of an anterior chamber intraocular lens.

We present a patient with a history of posterior chamber intraocular lens (PC IOL) implantation and trabeculotomy 9 years previously who recently had IOL exchange for an angle-based anterior chamber IOL. Twenty-four hours after the exchange, he was referred to us with hypotony and "loss" of the IOL. Ultrasound revealed a rigid choroidal detachment and echoes suggestive of a suprachoroidally dislocated IOL.

Prolonged retinal arteriovenous passage time is correlated to ocular perfusion pressure in normal tension glaucoma.

Background: The pathogenesis of normal tension glaucoma (NTG) might be related to impaired autoregulation of ocular blood flow. The purpose of the study is to evaluate retinal haemodynamics by fluorescein angiography and to correlate arteriovenous passage times (AVP) with ocular perfusion pressure in patients with NTG and controls.

Methods: Thirty-five patients with NTG without any topical treatment (mean age 53 +/- 11 years) and 35 age-matched controls (mean age 53 +/- 11 years) were included in this study.

Dronabinol and retinal hemodynamics in humans.

Purpose: To investigate the effects of oral cannabinoids on retinal hemodynamics assessed by video fluorescein angiography in healthy subjects.

Design: Interventional study.

Methods: In a self-experiment, the cannabinoid dronabinol (delta-9-tetrahydrocannabinol [THC]) was administered orally to eight healthy medical doctors (7.

Retrobulbar haemodynamics and contrast sensitivity improvements after CO2 breathing.

Purpose: Effects of gas mixtures have been widely studied. Carbon dioxide (CO(2)) is known to act as a vasodilator, whereas oxygen (O(2)) acts as a vasoconstrictor. Therefore, the interpretation of results is difficult.

Asymmetric visual field loss and retrobulbar haemodynamics in primary open-angle glaucoma.

Purpose: To investigate interocular differences in retrobulbar flow velocities in patients with asymmetric glaucomatous visual field loss.

Methods: Twenty-five patients with primary open-angle glaucoma (POAG) and asymmetric visual field loss were included in this study. Asymmetric visual field loss was defined as a difference of the global index mean deviation (MD) >6 dB between the two eyes.

Fluorescein filling defects of the optic nerve head in normal tension glaucoma, primary open-angle glaucoma, ocular hypertension and healthy controls.

Background: To evaluate fluorescein filling defects of the optic nerve head in normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), ocular hypertension (OHT) and controls.

Methods: Forty patients with NTG (mean age 55 +/- 10 years), 40 patients with POAG (mean age 55 +/- 11 years), 40 patients with OHT (mean age 53 +/- 13 years), and 40 age-matched controls (mean age 54 +/- 11 years) were included in a prospective study. Video fluorescein angiograms were performed by means of a scanning laser ophthalmoscope.

Effect of different irrigating solutions on aqueous humour pH changes, intraocular pressure and histological findings after induced alkali burns.

Purpose: To evaluate the effects of hypo-osmolar tap water and isotonic saline solution on the intracameral pH, intraocular pressure and histological changes in alkali burned rabbit eyes.

Methods: Four groups of four rabbit corneas each were burned with 2 N sodium hydroxide, and then rinsed with 0.5 l or 1.

Topical dorzolamide increases pericentral visual function in age-related maculopathy: pilot study findings with short-wavelength automated perimetry.

Purpose: Numerous studies have confirmed the enhancement of ocular circulation by carbonic anhydrase inhibitors (CAIs). Topical CAI treatment with dorzolamide averts the significant pericentral visual function loss accompanying retinal and choroidal vasoconstriction during acute hyperventilation-induced hypocapnia. This study was designed to discern whether dorzolamide might similarly enhance macular function in patients with age-related maculopathy (ARM).

Fluorescein leakage of the optic disc in glaucomatous optic neuropathy.

Purpose: To identify and quantify the role of capillary leakage of the optic nerve head in digital fluorescein angiography in normal subjects and patients with open-angle glaucoma.

Methods: We conducted a prospective cross-sectional study in the Department of Ophthalmology of the Technical University of Aachen. Thirty patients with primary open-angle glaucoma (POAG) and 30 healthy age-matched subjects were included.

Pathogenetic aspects of the glaucomatous optic neuropathy: fluorescein angiographic findings in patients with primary open angle glaucoma.

Purpose: To identify and quantify the role of retinal circulation, capillary leakage and/or nonperfusion of the optic nerve head in digital fluorescein angiography in normal subjects and patients with open angle glaucoma.

Methods: Eighteen patients with primary open angle glaucoma (POAG) and 18 healthy age matched subjects were included. Fluorescein angiograms were performed using the scanning laser ophthalmoscope.

Fluorescein filling defects and quantitative morphologic analysis of the optic nerve head in glaucoma.

Objectives: To evaluate absolute filling defects of the optic nerve head in normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) and to compare the filling defects with topographic analysis of the optic disc.

Methods: Twenty-five patients with NTG, 25 patients with POAG, and 25 age-matched controls were included. Fluorescein angiograms were performed by means of a scanning laser ophthalmoscope.

Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.

Purpose: The purpose of this prospective, randomized, cross-over study was to investigate and compare the microcirculatory effects of timolol, dorzolamide and latanoprost in newly diagnosed primary open-angle glaucoma (POAG) patients. Haemodynamics were assessed using fluorescein angiography by means of a scanning laser ophthalmoscope (SLO). Visual function and visual field indices were evaluated during all drug treatment phases.

Short-wavelength automated perimetry in patients with diabetes mellitus without macular edema.

Background: The short-wavelength-sensitive (SWS) cone-mediated sensitivity is a sensitive indicator of functional changes of the macula in diabetic maculopathy. This study was performed to investigate whether functional losses of the macula are detectable in patients without a significant macular edema.

Methods: In 45 patients with diabetes mellitus with clear optical media and no macular edema, conventional white-on-white perimetry (WWP) and short-wavelength automated perimetry (SWAP) were performed in the central 10-deg field.