Publications by authors named "Andreas Kiesow"

Adjunctive treatment of periodontitis lacks solutions which allow for enough time for wound healing in the periodontal pockets by avoiding fast re-colonization. Such a solution might be an antibiotic-containing formulation with a controlled release over a period of weeks. Here, a recently described minocycline-containing approach is qualified for further clinical development by focusing on proof-of-concept, systemic burden, resistance development, and degradation studies.

View Article and Find Full Text PDF
Article Synopsis
  • The randomized study compared the effectiveness of in situ (iS) and in vitro (iV) protocols for remineralizing artificial enamel lesions using two types of toothpaste: one with fluoride and a placebo without fluoride.
  • Results showed that fluoride-treated samples had significantly better remineralization in the iV protocol compared to the iS protocol after 21 days.
  • The study concluded that simpler iV methods could be more efficient for evaluating toothpastes, as the remineralization results were comparable between the two approaches despite different protocols.
View Article and Find Full Text PDF

Background: Restorative solutions designed for edentulous patients such as dentures and their accompanying denture adhesives operate in the complex and dynamic environment represented by human oral physiology. Developing material models accounting for the viscoelastic behavior of denture adhesives can facilitate their further optimization within that unique physiological environment. This study aims to statistically quantify the degree of significance of three physiological variables - namely: temperature, adhesive swelling, and pH - on denture adhesive mechanical behavior.

View Article and Find Full Text PDF

Background: The various physical and chemical conditions within the oral cavity are hypothesized to have a significant influence on the behavior of denture adhesives and therefore the overall comfort of denture wearers. As such, this study aims to understand the influence of oral cavity physiological parameters such as temperature (17 to 52 °C), pH (2, 7, 10), and denture adhesive swelling due to saliva (20-120%) on the behavior of denture adhesives. This study further aims to emphasize the need for a collective approach to modelling the in-situ behavior of denture adhesives.

View Article and Find Full Text PDF

Introduction: The aim of this in vitro study was to assess the suitability of high-resolution time-of-flight secondary ion mass spectrometry (ToF-SIMS) for visualizing cross-sectional changes in human enamel microstructure and chemical composition during treatment and remineralization cycling of artificially generated caries lesions underneath an artificial plaque.

Methods: Treatments consisted of exposure to twice daily toothpaste/water slurries prepared from 0, 1,100, and 5,000 μg/g fluoride (F) NaF/silica toothpastes. In addition, treatments with slurries prepared from 1,100 μg/g F SnF2/silica toothpastes were done using 44Ca in the remineralization solution to allow for differentiation of newly formed mineral and exploration of incorporated metal dopants using ToF-SIMS.

View Article and Find Full Text PDF

Objectives:  The study aimed to develop and test an model to investigate the staining potential of mouth rinses on human enamel, considering alternating intake of black tea and tooth brushing, thus mimicking the situation in the oral cavity more realistically.

Materials And Methods:  Eight mouth rinses with six different active ingredients (benzydamine hydrochloride [BNZ], polyhexamethylene biguanide hydrochloride [PHMB], chlorhexidine digluconate [CHX], hexetidine gluconate [HEX], octenidine dihydrochloride [OCT] and octenidine dihydrochloride + 2-phenoxyethanol [OCTP]) and concentrations were tested. Sets of six halved human molar crowns were initially pretreated by soaking in artificial saliva (30 min).

View Article and Find Full Text PDF

Physiological parameters of the oral cavity have a profound impact on any restorative solutions designed for edentulous patients including denture adhesives. This study aims to mathematically quantify the influence of three such variables, namely: the temperature, pH, and the swelling of such adhesives under the influence of saliva on its mechanical behavior. The mathematical quantification is further aimed to implement a material model for such adhesives which considers the impact of such physiological factors.

View Article and Find Full Text PDF

Dentin hypersensitivity is an oral health concern affecting a large percentage of the world's adult population. Occlusion of the exposed dentinal tubules is among the treatment options available, and silver diammine fluoride (SDF) is an occluding agent used for interrupting or dampening the stimulus of the dental pulp nerves that produce pain. In addition to dentin permeability testing, the evaluation of desensitizing agents occluding dentinal tubules strongly relies on microscopic techniques, such as scanning electron microscopy (SEM).

View Article and Find Full Text PDF
Article Synopsis
  • The study compared time-of-flight secondary ion mass spectrometry (ToF-SIMS) with the microbiopsy technique to measure enamel fluoride uptake (EFU).
  • Enamel specimens were treated with various types of fluoride: sodium fluoride (NaF), stannous fluoride (SnF2), and amine fluoride (AmF), with AmF showing the highest EFU.
  • Both methods provided highly correlating results (r = 0.95), suggesting that ToF-SIMS could be a reliable alternative for evaluating near-surface enamel fluoride uptake.
View Article and Find Full Text PDF

Objectives:  The aim of this study was to test the influence of the amount of toothpaste on enamel cleaning efficacy.

Materials And Methods:  The hydrated silica-based test toothpaste (radioactive dentin abrasion: 60.19 ± 1.

View Article and Find Full Text PDF

Background: Toothbrushes require flexibility to access all dental surfaces and remove plaque effectively, but they should also aim to prevent or limit overbrushing and consequent damage to teeth and gums. In two studies, the physical properties and cleaning performance of specialist test toothbrushes with flexible necks were compared to a reference rigid-necked toothbrush.

Methods: In Study 1, a universal testing machine (Instron E 10,000) with a specially designed setup was used to test the deflection behaviour of toothbrush head and neck.

View Article and Find Full Text PDF

The introduction of a removable partial denture onto the dental arch significantly influences the mechanical stress characteristics of both the jawbone and oral mucosa. The aim of this study was to analyze the stress state caused by biting forces upon insertion of partial dentures into the assembly, and to understand the influence of the resulting contact pressure on its retention behavior. For this purpose, a numerical model of a removable partial denture is proposed based on 3D models developed using computer tomography data of the jawbone and the removable partial denture.

View Article and Find Full Text PDF

Objectives:  There are several hypotheses regarding how chlorhexidine (CHX) digluconate causes staining with the role of beverages, specifically the precipitation of anionic dietary chromogens onto adsorbed cations, the most probable cause. The aim of this study was to investigate and compare the staining potential of common beverages using an staining and brushing model to better understand the interactions between chromogens from different beverage categories and the teeth.

Materials And Methods:  Human enamel samples were exposed to a cyclic treatment of artificial saliva and 0.

View Article and Find Full Text PDF

Objective: Silver diamine fluoride (SDF) is effective in treatment of dentin hypersensitivity and caries lesions. However, the non-viscous solution does not easily allow clinicians to control the application area. A 38% SDF experiment gel was compared in vitro to commercial SDF for its ability to penetrate and occlude dentinal tubules.

View Article and Find Full Text PDF

The base fit between a removable partial denture (RPD) and the underlying soft tissue plays a significant role in its performance. The application of a denture adhesive is hypothesized to result in better retention of RPDs and, as a result, contribute to lower stress on the oral mucosa. The objectives of this study were to observe and compare the distribution of simulated bite forces applied to the RPD through the abutments and soft tissue for models with and without the use of a denture adhesive.

View Article and Find Full Text PDF

The topical fluoride treatment of teeth can lead to a formation of CaF2-like material, which is considered to play a significant role in caries prevention. Different types of fluoride sources are applied. The aim of this study was to analyse the in vitro fluoridation effect of the lesser known organic fluoride compound nicomethanol hydrofluoride (NH) regarding fluoride accumulation and morphological changes on dental enamel surfaces.

View Article and Find Full Text PDF

Objective:  Oral care formulations aim to prevent oral diseases such as dental caries and gingivitis. Additionally, desire for white teeth still exists across all age groups. It is known that most whitening toothpastes are highly abrasive and can be harmful to teeth and gingiva.

View Article and Find Full Text PDF

Two-piece abutments consisting of customized zirconia abutment copings and prefabricated titanium bases are popular due to their biological and esthetic advantages. Glass-ceramic solder (GS) is an alternative biocompatible connective agent. This in vitro study evaluated the retentive force of GS in comparison to classical resin composite cements (RC) after artificial aging and autoclaving.

View Article and Find Full Text PDF

We describe the development of flexible minocycline-lipid-complex extrudates with optimized mechanical and drug release properties. These extrudates contain a minocycline - magnesium stearate chelate complex with a higher stability in aqueous media, which has now been incorporated in a PEG-PLGA (polyethylene glycol - poly(lactic-co-glycolic acid)) matrix. PEG 1500 has been utilized in different concentrations to serve as plasticizer.

View Article and Find Full Text PDF

Periodontal therapy using antimicrobials that are topically applied requires slow or controlled release devices. The in vitro antimicrobial activity of biodegradable polymer formulations that contain a new minocycline lipid complex (P-MLC) was evaluated. The new P-MLC formulations that contained 11.

View Article and Find Full Text PDF

The objective of this study was to develop an improved drug delivery system for the local antimicrobial treatment of periodontitis, that offers enhanced drug stability, easy application and controlled release over several weeks. Chelate complexes consisting of a tetracycline antibiotic and a fatty acid salt were developed. Minocycline and doxycycline were paired with magnesium- and calcium stearate in different molar ratios.

View Article and Find Full Text PDF

To avoid pathogen-associated molecular pattern recognition, the hemibiotrophic maize pathogen Colletotrichum graminicola secretes proteins mediating the establishment of biotrophy. Targeted deletion of 26 individual candidate genes and seven gene clusters comprising 32 genes of C. graminicola identified a pathogenicity cluster (CLU5) of five co-linear genes, all of which, with the exception of CLU5b, encode secreted proteins.

View Article and Find Full Text PDF

One infection mechanism of plant viruses is the generation of nanotubes by viral movement proteins, allowing cell-to-cell virus particle transport. Previously, it was assumed that viral nanotubes extend directly from the host-cell plasma membrane. In virus-infected plants, these nanotubes reach an extraordinary diameter:length ratio (≈100 nm:µm or mm range).

View Article and Find Full Text PDF

Statement Of Problem: Regular denture cleaning is essential to good oral health, but only limited evidence is available regarding the effects of common cleaning routines.

Purpose: The purpose of this in vitro study was to determine the compatibility of denture materials with and the antimicrobial effects of typical cleaning regimens.

Material And Methods: The evaluated treatments were derived from a study of dental professional recommendations and consumer habits, including denture cleanser tablets, toothpaste, mouthwash, isopropyl alcohol (IPA), household bleach, soap, and vinegar.

View Article and Find Full Text PDF

This study aimed to investigate the surface zones of acidic fluoride-treated enamel. Human teeth were each divided into three or four enamel specimens that were treated for 10 min with solutions of 0.2 and 0.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: