Publications by authors named "Andreas Jern"
Background: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases.
View Article and Find Full Text PDFBackground: Systemic lupus erythematosus (SLE) is a complex disease characterized by autoimmunity toward apoptotic cells, excessive amounts of circulating immune complexes, and complement activation. A decreased platelet size has been observed in SLE and their nonhemostatic functions may play an active role in the disease. The main objective of this study was to find clues that could explain their decreased size and functional role, analyzing the entire platelet proteome.
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- Platelets play a significant role in immune response in systemic lupus erythematosus (SLE), but studies on mean platelet volume (MPV) in SLE patients are limited and often inconsistent.
- In a study of 212 SLE patients, most showed low variation in MPV over time, with no significant link found between MPV and disease activity.
- The average MPV in SLE patients was smaller than in healthy controls, and those with smaller platelets were more likely to meet specific disease criteria, suggesting the need for further research into MPV as a potential biomarker in SLE.
Silver nanoparticles (AgNPs) are commonly used in commercial and medical applications. However, AgNPs may induce toxicity, extracellular matrix (ECM) changes and inflammatory responses. Fibroblasts are key players in remodeling processes and major producers of the ECM.
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