Publications by authors named "Andreas J P M Smout"

Article Synopsis
  • A study was conducted to explore how STW5 (Iberogast) might alleviate heartburn in patients with functional dyspepsia and reflux symptoms, focusing on its effect on esophageal sensitivity and motility.
  • In a double-blind, placebo-controlled trial with 18 patients, STW5 showed no significant difference overall in reflux symptom scores compared to placebo, but it did reduce certain specific scores related to gastroesophageal reflux disease.
  • The treatment also demonstrated a reduction in acidic reflux events in patients with gastroesophageal reflux disease and increased time before acid perception in those with reflux esophagitis, suggesting STW5 may help reduce esophageal hypersensitivity.
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Introduction: Although inability to belch has previously been linked to dysfunction of the upper esophageal sphincter (UES), its underlying pathogenesis remains unclear. Our aim was to study mechanisms underlying inability to belch and the effect of UES botulinum toxin (botox) injections in these patients.

Methods: We prospectively enrolled consecutive patients with symptoms of inability to belch.

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Background: Although nighttime reflux symptoms are common, the presence of nocturnal reflux is seldom confirmed with a standard 24 hours pH study.

Aim: To study patients with supine nighttime reflux symptoms using prolonged wireless pH monitoring.

Methods: In this retrospective study, patients with typical acid reflux symptoms were studied using 96-h pH monitoring.

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Introduction: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms.

Methods: We prospectively enrolled consecutive patients referred for upper endoscopy and collected histological, clinical, and endoscopic data.

Results: Of the 301 included patients, 14 (4.

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Background: Accurate information on the natural course of giant paraesophageal hernia is scarce, challenging therapeutic decisions whether or not to operate.

Objective: We aimed to investigate the long-term outcomes, including hernia-related deaths and complications (e.g.

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Establishing normative values of high-resolution esophageal manometry is necessary for accurate interpretation and comparison of measurements. In this systematic review, we aimed to summarize normal values for different esophageal high-resolution manometry systems. Moreover, we assessed the effect of body position, bolus consistency, and provocative maneuvers on these normative thresholds.

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Background & Aims: Identification of factors associated with achalasia treatment outcome might help physicians select therapies based on patient characteristics. We performed a systematic review and meta-analysis to identify factors associated with treatment response.

Methods: We searched MEDLINE, EMBASE, and the Cochrane Library through February 21, 2019, for randomized controlled trials and cohort, case-control, and cross-sectional studies that reported patient-specific outcomes of treatment (botulinum toxin injection, pneumatic dilation, peroral endoscopic myotomy, or laparoscopic Heller myotomy).

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Background: Eosinophilic esophagitis (EoE) is a chronic esophageal inflammation that may lead to stricture formation. This narrowing can cause major complications including food impactions. Despite increasing interest in EoE accurate data on its natural course is scarce.

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Skin tests and measurement of serum levels of immunoglobulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic esophagitis (EoE). We investigated whether an esophageal prick test, in which the esophageal mucosa is challenged by local injection of allergen extracts, could identify individuals with esophageal sensitization. During endoscopy, 6 allergens were injected in the esophagus of 8 patients with EoE and 3 patients without EoE (controls).

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In eosinophilic esophagitis (EoE), the esophageal barrier integrity is impaired. Integrity can be assessed with different techniques. To assess the correlations between esophageal eosinophilia and various measures of mucosal integrity and to evaluate whether endoscopic impedance measurements can predict disease activity, endoscopies and mucosal integrity measurements were performed in adult EoE patients with active disease (≥15 eosinophils/high-power field) at baseline ( = 32) and after fluticasone ( = 15) and elemental dietary treatment ( = 14) and in controls ( = 19).

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Objectives: The esophageal mucosal integrity is impaired in eosinophilic esophagitis (EoE) and it has been suggested that the duodenal permeability is increased. The absence of food allergens may restore the integrity. The aims of this study were to assess duodenal permeability in EoE and to evaluate the effect of an elemental diet on the esophageal and duodenal integrity.

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Article Synopsis
  • The study investigates the impact of fluticasone propionate on esophageal mucosal integrity in adults with eosinophilic esophagitis (EoE), noting that the condition impairs this integrity.
  • After an 8-week treatment with fluticasone, significant reductions in eosinophil and mast cell counts were observed, along with improvements in measures of mucosal barrier integrity such as increased electrical impedance and resistance.
  • The treatment also led to decreased inflammatory cytokines and increased expression of proteins linked to mucosal barrier function, suggesting that fluticasone not only alleviates inflammation but also enhances the protective barrier of the esophagus.
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Background: Eosinophilic esophagitis (EoE) is a chronic antigen-mediated disease histologically characterized by eosinophil-predominant inflammation. One-third of patients respond to proton pump inhibitor (PPI) treatment; this group is identified as having PPI-responsive esophageal eosinophilia (PPI-REE). If we could predict the response to PPIs on the basis of endoscopic signs, futile treatment efforts and additional endoscopies to assess treatment response can be prevented.

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Background: During the natural course of eosinophilic esophagitis (EoE), the risk for esophageal stricture formation increases. It remains unknown whether motility abnormalities in EoE also develop over time. We aimed to determine the relationship between disease duration, clinical characteristics, and manometric pattern of EoE patients.

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Article Synopsis
  • * In a study of 16 EoE-suspected patients and 11 controls, findings indicated that both patient groups had reduced electrical resistance and tissue impedance compared to controls.
  • * Although PPI therapy improved mucosal integrity in patients with PPI-REE, it did not have the same effect on those with EoE, suggesting different underlying mechanisms for these conditions.
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