Comparison of pulmonary deposition of nebulized technetium-diethylenetriamine-pentaacetic acid through 3 inhalation devices in healthy dogs.

Background: Inhalation treatment frequently is used in dogs and cats with chronic respiratory disease. Little is known however about the performance of delivery devices and the distribution of aerosolized drugs in the lower airways.

Objective: To assess the performance of 3 delivery devices and the impact of variable durations of inhalation on the pulmonary and extrapulmonary deposition of nebulized technetium-diethylenetriamine-pentaacetic acid ( Tc-DTPA).