Publications by authors named "Andreas H Brunner"
Article Synopsis
- - The study investigates the role of PAX 8, a transcription factor important for organ development, in endometrial carcinoma and its relationship with p53 expression.
- - Out of 106 patients with primary endometrial carcinoma, 72.1% showed PAX 8 expression, with a positive correlation found between PAX 8 and p53 levels, as well as histological type and grade.
- - Despite PAX 8 being commonly expressed in both types of endometrial carcinomas, it did not show a significant association with patient survival, indicating it might not be a useful prognostic marker.
Objective: The objective of the study was to evaluate the association between human papillomavirus (HPV) infection and clinical-pathological parameters in primary squamous cell carcinoma of the vagina and assess the value of HPV infection as a prognostic parameter.
Methods: In our retrospective study, we identified 37 consecutive patients with primary invasive squamous cell carcinoma of the vagina; 35 patients were eligible for further investigations. Human papillomavirus detection was assessed by in situ hybridization assays from paraffin-embedded tissue blocks.
OBJECTIVE.: The most frequently mutated gene in human cancer is p53, a gene that functions in the checkpoint response to DNA double-strand breaks. γ-H2AX is a marker of activated DNA damage and is overexpressed in many malignancies and their precursor lesions.
View Article and Find Full Text PDFBackground: Limited data are available to evaluate the accuracy of frozen section analysis and ultrasound- guided core needle biopsy of the breast.
Methods: In a retrospective analysis data of 120 consecutive handheldultrasound- guided 14- gauge automated core needle biopsies (CNB) in 109 consecutive patients with breast lesions between 2006 and 2007 were evaluated.
Results: In our outpatient clinic120 CNB were performed.
Background: Limited data are available for the accuracy of intraoperative frozen section analysis of inguinal sentinel lymph node in patients with vulvar cancer.
Patients And Methods: Forty-four patients with vulvar cancer treated with separate incisions for inguinal sentinel lymph node dissection between 2001 and 2007 were evaluated in the present study.
Results: Out of 44 patients, 3 had a false-negative intraoperative frozen section result due to micrometastasis.