GE-145, a new low-osmolar dimeric radiographic contrast medium.

Background: Contrast-induced nephrotoxicity is a significant risk when using radiographic contrast media clinically, especially in high risk patients. Consequently, there is a need for a new contrast agent with improved clinical safety with regards to nephrotoxicity.

Purpose: To evaluate the physicochemical properties as well as the preclinical safety and biodistribution parameters of the newly developed radiographic contrast medium GE-145.

Increase of signal-to-noise of more than 10,000 times in liquid state NMR.

Extract: Two major applications exist for Nuclear Magnetic Resonance (NMR): spectroscopy and imaging. NMR spectroscopy has gained acceptance as one of the major analytical techniques, due to the detailed information that can be obtained about molecular structure, dynamics and intra- and inter-molecular interactions. Magnetic resonance imaging (MRI) is a non-invasive technique with superior soft tissue contrast and broad diagnostic value.

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.

A method for obtaining strongly polarized nuclear spins in solution has been developed. The method uses low temperature, high magnetic field, and dynamic nuclear polarization (DNP) to strongly polarize nuclear spins in the solid state. The solid sample is subsequently dissolved rapidly in a suitable solvent to create a solution of molecules with hyperpolarized nuclear spins.