Comparison of adenosine-independent pressure indices to fractional flow reserve in stent-jailed bifurcation side branches.

Objectives And Background: This study aims to evaluate whether the high correlation and classification agreement of the instantaneous wave-free ratio (iFR) and the resting distal coronary to aortic pressure ratio (P /P ) with the fractional flow reserve (FFR) can be confirmed in stent-jailed side branches (J-SB).

Methods: Consecutive patients (n = 49) undergoing provisional stenting were prospectively enrolled and a physiological assessment of the J-SB (n = 51) was performed. FFR, iFR, and P /P were measured and the hemodynamic relevance was determined using cutoff values of ≤0.

Investigations of the water clusters of the protected amino acid Ac-Phe-OMe by applying IR/UV double resonance spectroscopy: microsolvation of the backbone.

In order to investigate the influence of hydration on the backbone of a peptide or protected amino acid, the successive aggregation of water to Ac-Phe-OMe is analysed by means of IR/UV double resonance spectroscopy. To achieve meaningful results the spectra have been recorded in the region of the amide A and OH stretching vibrations as well as the amide I/II modes. Comparison with ab initio and DFT calculations leads to size-selective structural assignments.

Proton/hydrogen-transfer coordinate of 2,5-dihydroxybenzoic acid investigated in a supersonic beam: combined IR/UV spectroscopy in the S0, S1, and D0 states.

As a model system for intramolecular proton/hydrogen-transfer coordinates, the structure of 2,5-dihydroxybenzoic acid is investigated for the ground, first electronically excited and also the ionic state. Combined IR/UV spectroscopy in molecular-beam experiments is applied and the experimental results are interpreted by the application of DFT and CASPT2 methods. No proton or hydrogen transfer is observed, but evidence is given for a hydrogen dislocation of the intramolecular hydrogen bond in the S(1) state and to lesser extent in the D(0) state.