Publications by authors named "Andreas G Hadjigeorgiou"
Pancreatic cancer remains one of the most lethal malignancies, with limited treatment options and poor prognosis. A common characteristic among pancreatic cancer patients is the biomechanically altered tumor microenvironment (TME), which among others is responsible for the elevated mechanical stresses in the tumor interior. Although significant research has elucidated the effect of mechanical stress on cancer cell proliferation and migration, it has not yet been investigated how it could affect cancer cell drug sensitivity.
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- The study investigates how tumor-resident mast cells (MC) influence cancer-associated fibroblasts (CAF) to improve the tumor microenvironment (TME) and enhance the effectiveness of immune-checkpoint inhibitors in sarcoma.
- Researchers utilized a coculture system and mouse models to explore the impact of ketotifen, an MC stabilizer and antihistamine, in combination with chemotherapy and anti-PD-L1 treatment.
- Results show that ketotifen decreased CAF proliferation and tumor stiffness, improved blood flow and oxygenation in tumors, and enhanced T-cell activity, underscoring its potential in improving immunotherapy responses in sarcoma patients.*
Mechanical stresses in solid tumors play an important role in tumor progression and treatment efficacy but their quantification is under-investigated. Here, we developed an experimental and computational approach to calculate growth-induced, residual stresses and applied it to the breast (4T1), pancreatic (PAN02), and fibrosarcoma (MCA205) tumor models. Following resection, tumors are embedded in agarose gels and cuts are made in two perpendicular directions to release residual stress.
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