Evaluation of signal transduction pathways after transient cutaneous adenoviral gene delivery.

Background: Adenoviral vectors have provided effective methods for in vivo gene delivery in therapeutic applications. However, these vectors can induce immune responses that may severely affect the ability of vector re-application. There is limited information about the mechanisms and signal transduction pathways involved in adenoviral recognition.

[The pedicled groin flap for defect closure of the hand].

Objective: Soft-tissue defect closure of the volar and dorsal aspect of the hand and lower arm with a maximum defect size of 10 × 25 cm.

Indications: Soft-tissue defects of the entire palm and dorsum of the hand and lower arm with a maximum defect size of 10 × 25 cm.

Contraindications: Polytraumatized patients presenting with concomitant life-threatening injuries.

Insight in microcirculation and histomorphology during burn shock treatment using in vivo confocal-laser-scanning microscopy.

Purpose: Microcirculatory disturbances are well known during shock; however, the accompanied histomorphological alterations are widely unknown. We used high resolution confocal-laser-scanning microscopy for the evaluation of microcirculation and histomorphology during Burn Shock treatment.

Methods: Confocal-laser-scanning microscopy was performed in 10 burn shock patients (4 women, 6 men; aged 40.

In vivo evaluation of histomorphological alterations in first-degree burn injuries by means of confocal-laser-scanning microscopy-more than "virtual histology?".

There are various approaches to the treatment of superficial burns. No modality exists to date for determining treatment efficiency on morphological features. We review the first application of high-resolution in vivo confocal-laser-scanning microscopy (CLSM) to the evaluation of superficial burns on a histomorphological level.

The free latissimus dorsi flap as primary free flap and crane flap with secondary pedicled transfer.

We are reporting a case of a 43-year-old woman, who developed a soft tissue defect of the knee region following complex lower limb trauma. The defect was covered with a microvascular latissimus dorsi (LD) flap. The patient required a total knee replacement and developed a defect at the anterior aspect of the knee.