Publications by authors named "Andreas Bolzer"
Background: Activation of the immune system in terms of subseptic conditions during liver regeneration is of paramount clinical importance. However, little is known about molecular mechanisms and their mediators that control hepatocyte proliferation. We sought to determine the functional role of immune cells, especially NKT cells, in response to partial hepatectomy (PH), and to uncover the impact of the integrin lymphocyte function-associated antigen-1 (LFA-1) on liver regeneration in a subseptic setting.
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- IFNgamma helps our immune system by activating important genes in a part of our DNA called the MHC.
- A special process called JAK/STAT signalling makes the DNA open up so that these genes can be turned on.
- If there's a tiny mistake in a protein called STAT1, this opening doesn't happen, which shows how important these signals are for our DNA's structure and function.
Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to explore changes in epigenome structure and their functional implications during development and cell differentiation. However, the extent and cell-type-specificity of three-dimensional (3D) chromosome arrangements has remained controversial. In order to overcome technical limitations of previous studies, we have developed tools that allow the quantitative 3D positional mapping of all chromosomes simultaneously.
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