Three-column intermittent simulated moving bed chromatography: 2. Experimental implementation for the separation of Tröger's Base.

The three-column intermittent simulated moving bed (3C-ISMB) process has been presented in the first part of this series [1]. A theoretical comparative analysis of the new process to intermittent simulated moving bed (I-SMB) demonstrated successfully the potential of the 3C-ISMB technology. Particularly, 3C-ISMB was shown to substantially outperform I-SMB in terms of productivity whilst maintaining high purity specifications and without significantly sacrificing solvent consumption.