Molecular Docking, Synthesis And Biological Evaluation Of Ergosteryl-Ferulate As A Hmg-Coa Reductase Inhibitor.

In the present study, ergosteryl-ferulate (5), oryzanol analog was evaluated for its possibility as the inhibitor of hmg-coa reductase (hmgr), through in silico and in vitro approach. firstly, the study was conducted through molecular docking simulation using autodock tools software to predict the interaction of 5 in complexes with hmgr. in addition, four major compounds of oryzanol (1-4) were employed as a comparison.

Kidney therapeutic potential of peptides derived from the bromelain hydrolysis of green peas protein.

Objectives: Kidney disease is a global health problem that needs a solution to its therapy. In the previous study, we found that protein hydrolysate of green peas origin of Indonesia hydrolysed by bromelain (PHGPB) showed improve kidney function in cisplatin-induced nephropathy rats. In this study, we investigated the effect of PHGPB to obtain effective dose that exerts a therapeutic effect on chronic kidney disease (CKD) based on reducing urea and creatinine levels and to elucidate its mechanism of action.