Publications by authors named "Andrea de Farias Fernandes Belone"
Article Synopsis
- A clinical trial tested the effectiveness of multidrug therapy (MDT) for leprosy, with some patients receiving itraconazole, while others did not follow any treatment regimen.
- Results showed that patients receiving MDT (with or without itraconazole) had a significantly higher cure rate compared to the control group, but adding itraconazole did not improve outcomes, indicating that MDT alone is sufficient for treatment.
Simultaneous analysis of multiple T helper subsets in leprosy reveals distinct patterns of Th1, Th2, Th17 and Tregs markers expression in clinical forms and reactional events.
Michelle de Campos Soriani Azevedo Heloisa Marques Larissa Sarri Binelli Mariana Silva Vieira Malange Amanda Carreira Devides Andrea de Farias Fernandes Belone
Med Microbiol Immunol
December 2017
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Previous studies have demonstrated that the difference among clinical forms of leprosy can be associated with the immune response of patients, mainly by T helper (Th) and regulatory T cells (Tregs). Then, aiming at clarifying the immune response, the expression of cytokines related to Th1, Th2, Th17 and Tregs profiles were evaluated by qPCR in 87 skin biopsies from leprosy patients.
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