Publications by authors named "Andrea Werbach"
Article Synopsis
- The PI3K/AKT/mTOR pathway is important in the progression and recurrence of breast cancer, with specific mutations and loss of PTEN serving as targets for therapies.
- A study examines phosphorylated ribosomal protein S6 (pS6) as a marker for PI3K pathway activation and its association with recurrence-free survival in early-stage breast cancer patients.
- Findings indicate that a high level of pS6-positive tumor cells correlates with worse prognosis, suggesting it could be a new independent marker for predicting recurrence risk in hormone receptor-positive/HER2-negative breast cancer.
Article Synopsis
- Resistance to therapy is a significant challenge in managing cancer, particularly in luminal breast cancer where hormone and CDK4/6 inhibitors often fail.
- This study explored mechanisms of resistance using various cell lines and patient-derived cells, examining how specific kinase inhibitors affect cancer cell survival and aggressiveness.
- The findings suggest that mTOR inhibitors are more effective than PI3K inhibitors in tackling this resistance, and combining mTOR with CDK4/6 inhibitors could enhance treatment outcomes and prevent cancer recurrence.
The pathological diagnosis of diffuse pleural mesothelioma (DPM) contributes to treatment selection and clinical trials interpretation. To know its characteristics and evaluate the viability of comprehensive pathological diagnosis of DPM in Argentina we did a retrospective descriptive study of DPM cases reported from 2009 to 2018. We analyzed 398 cases corresponding to 238 (60%) men and 160 (40%) women, median age 66 years, from surgical biopsies (78%), small biopsies (16.
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