Publications by authors named "Andrea Vilarrubi"
Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. We report complete refractoriness to IFNγ in a subset of LCs as a result of JAK2 or IFNGR1 inactivation.
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- Scientists found that tumors missing a gene called SMARCA4 don't have good treatments yet.*
- They discovered that these SMARCA4-deficient cells can't handle a specific drug and need other special proteins to survive.*
- By using a new drug that targets those special proteins, they were able to shrink tumors in mice, suggesting a possible new way to treat patients with this type of cancer.*