Publications by authors named "Andrea Tichy"
Article Synopsis
- - Patients with recessive dystrophic epidermolysis bullosa (RDEB) have issues with type VII collagen due to mutations in the COL7A1 gene, leading to severe skin problems and a risk of cancer.
- - Researchers developed a method to create corrected skin cells from these patients using induced pluripotent stem cells (iPSCs), which were successfully edited to produce functional type VII collagen.
- - The study shows that these corrected iPSC-derived keratinocytes can form healthy skin in lab tests and could potentially provide a new treatment approach for RDEB patients, minimizing the risk of cancer by selecting cells with fewer mutations.
Background: Lymphatic malformations can be challenging to treat. Mainstay interventions including surgery and sclerotherapy are invasive and can result in local recurrence and complications.
Objective: We sought to assess the effect of 20 weeks of oral sildenafil on reducing lymphatic malformation volume and symptoms in children.
Olfaction depends on the differential activation of olfactory receptor neurons (ORNs) and on the proper transmission of their activities to the brain. ORNs select individual receptors to express, and they send axons to particular targets in the brain. Little is known about the molecular mechanisms underlying either process.
View Article and Find Full Text PDFCytokinesis in most eukaryotes requires the assembly and contraction of a ring of actin filaments and myosin II. The fission yeast Schizosaccharomyces pombe requires the formin Cdc12p and profilin (Cdc3p) early in the assembly of the contractile ring. The proline-rich formin homology (FH) 1 domain binds profilin, and the FH2 domain binds actin.
View Article and Find Full Text PDF