Publications by authors named "Andrea Storai"
Dendrimers are efficient drug delivery systems particularly useful in ocular diseases. In particular, low generation PAMAM dendrimers are non-toxic and non-immunogenic and they provide an enhancement of the residence time of drugs in the eyes. In this context, the synthesis of the PAMAM-based matrix metalloproteinases inhibitor 5, is reported.
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- The study focuses on creating and analyzing Ln complexes with a DOTA-based inhibitor designed to target matrix metalloproteinases.
- The presence of the Ln-DOTA component does not interfere with the inhibitor's strong binding to the enzyme's catalytic domain.
- The magnetic properties of the Ln complex are utilized to understand ligand-protein interactions and assess how variations in the linker length affect paramagnetic restraints.