Publications by authors named "Andrea Stingu"
Article Synopsis
- Targeted protein degradation is a new approach in drug discovery, but the natural half-life of proteins greatly influences how effective these degraders are, and this relationship hasn’t been thoroughly studied.
- Research shows that short-lived proteins can misleadingly appear to be degraded by agents that actually halt protein synthesis, like GSPT1 degraders and cytotoxic drugs.
- The findings indicate that understanding a target protein's half-life is crucial for selecting targets and designing control experiments to validate the effectiveness of new protein degrading agents.
