Publications by authors named "Andrea Salmaso"

Purpose: ATP2B2 encodes the variant-constrained plasma-membrane calcium-transporting ATPase-2, expressed in sensory ear cells and specialized neurons. ATP2B2/Atp2b2 variants were previously linked to isolated hearing loss in patients and neurodevelopmental deficits with ataxia in mice. We aimed to establish the association between ATP2B2 and human neurological disorders.

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Article Synopsis
  • Calcium (Ca) acts as a second messenger crucial for various cellular processes in bone, including the differentiation of osteoblasts, while mutations in TRIC-B can lead to a severe form of osteogenesis imperfecta (OI).
  • A study using specially modified mice showed that the absence of TRIC-B in osteoblasts significantly disrupts bone growth and structure, causing fractures due to delayed osteoblast differentiation and reduced collagen synthesis resulting from calcium imbalance.
  • The findings revealed that altered SMAD signaling driven by CaMKII-mediated pathways is primarily responsible for osteoblast dysfunction, with partial recovery achieved through TGF-β treatment, highlighting the vital roles of TRIC-B and CaMKII-SMAD signaling in bone health.
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Calcium concentration must be finely tuned in all eukaryotic cells to ensure the correct performance of its signalling function. Neuronal activity is exquisitely dependent on the control of Ca homeostasis: its alterations ultimately play a pivotal role in the origin and progression of many neurodegenerative processes. A complex toolkit of Ca pumps and exchangers maintains the fluctuation of cytosolic Ca concentration within the appropriate threshold.

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The plasma membrane calcium ATPase (PMCA) extrudes calcium from the cytosol to the extracellular space to terminate calcium-dependent signaling. Although the distribution of PMCA is crucial for its function, the molecular mechanisms that regulate the localization of PMCA isoforms are not well understood. PLEKHA7 is implicated by genetic studies in hypertension and the regulation of calcium handling.

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Pterostilbene (Pt) is a potentially beneficial plant phenol. In contrast to many other natural compounds (including the more celebrated resveratrol), Pt concentrations producing significant effects can also be reached with relative ease . Here we focus on some of the mechanisms underlying its activity, those involved in the activation of transcription factor EB (TFEB).

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Aim And Objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction.

Materials And Methods: This pilot retrospective case series describes the histologic and histomorphometric outcome of three patients who received the equine-derived bone paste in post-extractive sockets to allow the preservation of the alveolar ridge. Patients were later rehabilitated with monolithic-zirconia, implant-supported prostheses.

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Obesity and related comorbidities are a major health concern. The drugs used to treat these conditions are largely inadequate or dangerous, and a well-researched approach based on nutraceuticals would be highly useful. Pterostilbene (Pt), i.

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