NK cell defects: implication in acute myeloid leukemia.

Acute Myeloid Leukemia (AML) is a complex disease with rapid progression and poor/unsatisfactory outcomes. In the past few years, the focus has been on developing newer therapies for AML; however, relapse remains a significant problem. Natural Killer cells have strong anti-tumor potential against AML.

Identification of the HLA-B*40:01:02:59 and -C*05:01:73 alleles in individuals from the northern regions of India.

The novel HLA-B*40:01:02:59 and HLA-C*05:01:73 alleles were detected during the routine HLA typing process.

Identification of the novel HLA-A*01:01:01:111 allele in two individuals from Uttar Pradesh, India.

The novel HLA-A*01:01:01:111 allele was detected during routine HLA typing.

Detection of novel HLA-A*33:03:62, HLA-B*52:01:01:25 alleles and confirmation of HLA-A*02:01:209.

Novel HLA-A*33:03:62, -B*52:01:01:25 alleles and confirmatory HLA-A*02:01:209 allele were detected during the HLA typing process.

Identification of the novel HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 alleles in individuals from India.

The novel alleles HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 were detected during the routine HLA typing process.

Identification of the novel HLA-C*07:02:01:184 allele in an Indian individual from a Kshatriya family.

The novel allele HLA-C*07:02:01:184 as compared with HLA-C*07:02:01:03 displays polymorphism at position; gDNA 2896 (G > C).

The novel HLA-B*40:02:01:39 allele in an individual from a Kshatriya family in North India.

The novel allele, HLA-B*40:02:01:39 differs from the HLA-B*40:02:01:01 allele by a single nucleotide change at gDNA position 700.

Identification of the novel HLA allele, HLA-B*37:01:01:19, in an individual from northern India.

The novel allele HLA-B*37:01:01:19 differs from B*37:01:01:01 by one nucleotide A->G in Intron 3 at gDNA1430.

Identification of the novel HLA-DPA1*01:03:01:64 allele in an individual from Uttar Pradesh, India.

The novel HLA-DPA1*01:03:01:64 allele was detected during routine HLA typing.

Characterization of the novel HLA-B*58:01:01:19 allele by next-generation sequencing.

The novel HLA-B*58:01:01:19 allele was characterized using next generation sequencing technology.

Identification of the novel HLA allele, HLA-A*11:01:01:86, in an individual from north India.

The novel allele HLA-A*11:01:01:86 differs from HLA-A*11:01:01:86 by one nucleotide change at position; gDNA-32 (A- > C).

Identification of the novel HLA-DQA1*01:01:01:10 allele in an individual from Orissa, India.

The novel HLA-DQA1*01:01:01:10 allele differs from HLA-DQA1*01:01:01:07 by a single nucleotide change at gDNA 702 G T.

Identification of the novel HLA-A *24:02:01:136 allele in a Northern Indian individual from a Muslim family.

The novel allele HLA-A*24:02:01:136 as compared with HLA-A*24:02:01:01 displays a single nucleotide polymorphism at position; gDNA 2827 (C > A).

Identification of the novel HLA-C*12:02:47 allele in an individual from Maharashtra, India.

The novel HLA-C*12:02:47 allele was detected during routine HLA typing.

Characterization of the novel HLA allele, HLA-C*07:04:01:19, in an individual from Maharashtra, India.

HLA-C*07:04:01:19 differs from C*07:04:01:01 by one nucleotide change in gDNA at position 2420 in intron 5.

Identification of HLA-C*03:599 novel allele variant in two South Indian individuals in a Brahmin family.

The novel allele HLA-C*03:599 as compared with HLA-C*03:04:01:02 displays polymorphism at position; gDNA 1618 (G>T).

Identification of the novel allele, HLA-C*06:02:38:02, in a Gujarati individual from India.

The novel allele HLA-C*06:02:38:02 differs from HLA-C*06:02:38:01 by a nucleotide change at position; gDNA 168 T ➔ A.

Identification of the novel allele, HLA-A*02:11:01:06, in two North Indian individuals in a Kshatriya family.

The novel allele HLA-A*02:11:01:06 as compared with HLA-A*02:11:01:01 displays polymorphism at position; gDNA 1562 (C>A).

The novel HLA-B*52:01:01:23 allele in an individual from Uttar Pradesh, North India.

The novel HLA-B*52:01:01:23 allele differs from HLA-B*52:01:01:01 by a nucleotide change at gDNA-61 C➔A.

Identification of the novel HLA-DQB1*06:01:01:04 allele in an individual from Western India.

The novel HLA-DQB1*06:01:01:04 allele was detected during routine HLA typing.

Identification of the novel HLA allele, HLA-DRB1*14:245, in an individual from Northern India.

HLA-DRB1*14:245 differs from DRB1*14:54:01:01 by one nucleotide change in gDNA at position 7898 in exon 3.

Identification of the novel HLA-B*51:01:01:108 allele and confirmation of HLA-B*40:387 in two Indian individuals.

The HLA-B*51:01:01:108 and HLA-B*40:387 alleles were detected during routine HLA typing.