Publications by authors named "Andrea Roseli Vancan Russo Horimoto"
Many factors influence the incidence of type 2 diabetes mellitus (T2DM). Here, we investigated the associations between socio-demographic characteristics and familial history with the 5-year incidence of T2DM in a family-based study conducted in Brazil. T2DM was defined as baseline fasting blood glucose ≥ 126 mg/dL or the use of any hypoglycaemic drug.
View Article and Find Full Text PDFIntroduction: The engagement in sports or habitual physical activity (PA) has shown an extensive protective role against multiple diseases such as cancer, obesity, and many others. Additionally, PA has also a significant impact on life quality, since it aids with managing stress, preserving cognitive function and memory, and preventing fractures in the elderly.
Objective: Considering there has been multiple evidence showing that genetic variation underpins variation of PA-related traits, we aimed to estimate the heritability (h2) of these phenotypes in a sample from the Brazilian population and assess whether males and females differ in relation to those estimates.
Resistant hypertension (RH) is defined as uncontrolled blood pressure despite treatment with three or more antihypertensive medications, including, if tolerated, a diuretic in adequate doses. It has been widely known that race is associated with blood pressure control. However, intense debate persists as to whether this is solely explained by unadjusted socioeconomical variables or genetic variation.
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- Dysglycaemia refers to high blood glucose levels, which can lead to prediabetes and diabetes, and is associated with increased cardiovascular risks, prompting the study of its incidence and cardiometabolic risk factors over five years in a normoglycaemic sample.
- The analysis used data from the Baependi Heart Study, excluding individuals already diagnosed with diabetes or those on diabetes medications, and employed mixed-effects logistic regression to explore relationships between dysglycaemia and risk factors.
- The study found a 12.8% incidence of prediabetic dysglycaemia after five years, with waist circumference, systolic blood pressure, HDL cholesterol, and age being significant factors, while differences between sexes were noted in specific cardi
Article Synopsis
- This study aimed to evaluate four different measures of body fat (waist circumference, body mass index, body adiposity index, and visceral adiposity index) to see which is most closely linked to hypertension in a Brazilian population.
- The research involved 1,627 participants aged over 18 from Baependi, Brazil, and found that waist circumference and body mass index were significantly higher in individuals with hypertension.
- Results indicated that waist circumference was the best predictor of hypertension in men, while body mass index was more effective in women, suggesting these two measures could be useful for screening hypertensive patients.
Article Synopsis
- This study examined the relationship between genetic ancestry, self-identified race, and heart function in patients with chronic heart failure (HF).
- It involved 362 patients, aged 18 to 80, analyzing their genetic backgrounds and echocardiography results without finding significant differences in heart function based on race.
- The results indicated that African ancestry was linked to poorer diastolic heart function, while Amerindian ancestry was associated with reduced contractility, while self-declared race did not provide useful insights into heart function profiles.
Background: The stratum corneum (SC) has important functions as a bound-water modulator and a primary barrier of the human skin from the external environment. However, no large epidemiological study has quantified the relative importance of different exposures with regard to these functional properties. In this study, we have studied a large sample of individuals from the Brazilian population in order to understand the different relationships between the properties of SC and a number of demographic and self-perceived variables.
View Article and Find Full Text PDFBackground: Increased arterial stiffness predicts morbidity and mortality, independently of other cardiovascular risk factors, and glycemic control impairments are related to higher vascular stiffness. The aim of this study was to evaluate the association between HbA1c levels and increased arterial stiffness in a Brazilian rural population.
Methods: For this study were selected 1675 individuals (both genders and aged over 18 years) resident in the municipality of Baependi, a city located in the Southeast of Brazil.
Different approaches for dealing with rare variants in family-based genetic studies: application of a Genetic Analysis Workshop 17 problem.
BMC Proc
November 2011
Rare variants are becoming the new candidates in the search for genetic variants that predispose individuals to a phenotype of interest. Their low prevalence in a population requires the development of dedicated detection and analytical methods. A family-based approach could greatly enhance their detection and interpretation because rare variants are nearly family specific.
View Article and Find Full Text PDFBackground And Aim: Knowledge about the genetic factors responsible for noise-induced hearing loss (NIHL) is still limited. This study investigated whether genetic factors are associated or not to susceptibility to NIHL.
Subjects And Methods: The family history and genotypes were studied for candidate genes in 107 individuals with NIHL, 44 with other causes of hearing impairment and 104 controls.