Publications by authors named "Andrea Roche-Recinos"
Background: Low ionized calcium (ICa) is prevalent in critical care patients. It is poorly detected by the popular indirect method, which corrects serum total calcium (TCa) for change in albumin. That correction (cTCa) ignores any concomitant change in the anion-complexed fraction of TCa.
View Article and Find Full Text PDFBackground: There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patients to dialysis.
Methods: We designed an electronic survey with 39 questions and sent it to a database of practicing nephrologists at the National Kidney Foundation.
Article Synopsis
- The use of glycine distension solution in surgeries like transurethral prostatectomy (TURP) and hysteroscopy can lead to serious complications, including death, due to its toxic effects on the brain and the resulting hyperammonemia.
- Researchers propose that brain edema and mortality may actually be due to osmotic brain edema, caused by glycine selectively diffusing into the brain while sodium remains trapped inside due to the lack of sodium transporters in cerebral capillaries.
- This hypothesis explains the unidirectional diffusion of solutes into the brain during glycine-associated hyponatremia, challenging the previous understanding that the condition is non-toxic.
Objectives: Sodium concentration is measured by either indirect (I) or direct potentiometry (D), on chemistry and gas panels, respectively. A spurious difference between these methods (ΔNa=I-D) can be confusing to the clinician. For example, variation in serum total protein (TP) is well known to selectively interfere with I.
View Article and Find Full Text PDFPurpose Of Review: Antibody-mediated injury of renal allografts has assumed increasing importance with the availability of potent immunosuppressants directed against T-lymphocytes. Intravenous immunoglobulin (IVIG) has been used for prevention and treatment of antibody-mediated rejection. The review summarizes recent advances that shed light on mechanisms of action of IVIG and outlines current roles of IVIG in kidney transplantation.
View Article and Find Full Text PDFDiabetic kidney disease is a leading cause of end-stage kidney disease worldwide. Data suggest that prevention of progression to end-stage may lie in excellent blood glucose control; however, as kidney disease progresses, the risk of hypoglycemia increases, due to unpredictable insulin kinetics and altered pharmacokinetics of hypoglycemic agents. In addition, whole classes of hypoglycemic agents become contraindicated and regimens must be adjusted for declining kidney function.
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