Digital Migration of a Validated Cognitive Challenge Test in Mild Cognitive Impairment: Convergence of the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) and the Digital LASSI (LASSI-D) in older Participants with Amnestic MCI and Normal Cognition.

Background: The early detection of mild cognitive impairment (MCI) is crucial for providing treatment before further decline. Cognitive challenge tests such as the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L™) can identify individuals at highest risk for cognitive deterioration. Performance on elements of the LASSI-L, particularly proactive interference, correlate with the presence of critical Alzheimer's Disease (AD) biomarkers.

Improvements in performance based measures of functional capacity and cognition after computerized functional skills training in older people with mild cognitive impairment and healthy comparators.

With no pharmacological treatments for Mild Cognitive impairment (MCI), computerized training strategies have been attempted. A computerized skills training intervention, FUNSAT, previously produced training-related gains in cognition in MCI and in comparators with normal cognition (NC). A new remotely delivered version of FUNSAT was administered to a new sample of participants with NC and MCI.