Comprehensive evaluation of the impact of workplace exposures on physician-certified sick leave in the general working population.

Background: Our objective was to quantify the prospective associations between work factors across chemical, physical, mechanical, and psychosocial domains and the onset of medically certified sick leave.

Methods: Eligible respondents were interviewed in 2009, 2013, or 2016 and were registered in the national sick leave register with an employee relationship lasting more than 50 working days during the year of the survey interviews and the following year (n = 15,294 observations). To focus on the onset of high-level sick leave (HLSL; >16 days a year), we excluded individuals with HLSL during the survey year (baseline).

Adverse social behaviour at work and health-related employment exit: a prospective population-based four-wave survey.

Background: The level of evidence for various aspects of adverse social behaviour (ASB) at work as risk factors for exit from employment due to health problems or diseases is inconclusive.

Methods: We obtained data from four consecutive surveys (2006/09/13/16) of the general population of Norway. Respondents who were interviewed in two consecutive surveys and employed at the first survey time point constituted the sample (n = 17 110 observations).

Onset of Work-Life Conflict Increases Risk of Subsequent Psychological Distress in the Norwegian Working Population.

We aimed to assess whether the onset of work-life conflict is associated with a risk of subsequent onset of psychological distress. Respondents from a randomly drawn cohort of the general Norwegian working population were interviewed in 2009 (T1), 2013 (T2), and 2016 (T3) (gross sample = 13,803). Participants reporting frequent work-life conflict at T1 and/or psychological distress (five-item Hopkins Symptom Checklist mean score ≥ 2) at T2 were excluded to establish a design that allowed us to study the effect of the onset of work-life conflict at T2 on psychological distress at T3.

Work-life interference and physician-certified sick leave: a prospective study of a general working population.

Background: Work-life interference has been associated with adverse health outcomes. Here, we quantify the association between work-life interference and subsequent sick leave.

Methods: Respondents from a randomly drawn cohort of the general working Norwegian population were interviewed in 2009, 2013 and/or 2016.

The Relationship between Workplace Conflicts and Subsequent Physician-Certified Sick Leave: A Prospective Population Study.

The impact of workplace conflicts on sick leave is largely unknown. We studied the associations between conflicts and physician-certified sick leave in a randomly drawn general working population sample. Eligible respondents were interviewed in 2009, 2013, and 2016 and were registered with an employee relationship ≥50 working days in the national sick-leave register the year following the survey interviews ( = 22,088 observations/13,731 respondents).

Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids.

Many occupations require operations during the night-time when the internal circadian clock promotes sleep, in many cases resulting in impairments in cognitive performance and brain functioning. Here, we use a rat model to attempt to identify the biological mechanisms underlying such impaired performance. Rats were exposed to forced activity, either in their rest-phase (simulating night-shift work; rest work) or in their active-phase (simulating day-shift work; active work).

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex.

Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work could impair brain function and cognition through disrupted synthesis of proteins involved in synaptic plasticity and neuronal function.

A Rodent Model of Night-Shift Work Induces Short-Term and Enduring Sleep and Electroencephalographic Disturbances.

Millions of people worldwide are working at times that overlap with the normal time for sleep. Sleep problems related to the work schedule may mediate the well-established relationship between shift work and increased risk for disease, occupational errors and accidents. Yet, our understanding of causality and the underlying mechanisms that explain this relationship is limited.

Shift in Food Intake and Changes in Metabolic Regulation and Gene Expression during Simulated Night-Shift Work: A Rat Model.

Night-shift work is linked to a shift in food intake toward the normal sleeping period, and to metabolic disturbance. We applied a rat model of night-shift work to assess the immediate effects of such a shift in food intake on metabolism. Male Wistar rats were subjected to 8 h of forced activity during their rest (ZT2-10) or active (ZT14-22) phase.