Publications by Andrea Naegele

Publications by authors named "Andrea Naegele"

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Population-Based Evidence for the Use of Serum Neurofilaments as Individual Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis.

Simon Witzel André Huss Gabriele Nagel Angela Rosenbohm Dietrich Rothenbacher Andrea Naegele

Ann Neurol

December 2024

Article Synopsis

* In a study involving 790 ALS patients and 570 control participants, levels of NfL and pNfH were measured, revealing that NfL is more effective than pNfH for diagnostics and prognosis, especially when considering a new population-based ALS Z-score.
* The research highlights the importance of factors like age, ALS symptoms, body mass index (BMI), and kidney function in interpreting neurofilament levels, showing that with

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Cystatin C based estimation of chronic kidney disease and amyotrophic lateral sclerosis in the ALS registry Swabia: associated risk and prognostic value.

Gabriele Nagel Deborah Kurz Raphael S Peter Angela Rosenbohm Wolfgang Koenig Andrea Naegele

Sci Rep

November 2023

Kidney function as part of metabolic changes could be associated with amyotrophic lateral-sclerosis (ALS). We investigated the associations between estimated chronic kidney disease (CKD), based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C equation, and the risk at onset and prognostic value of CKD for ALS. Between October 2010 and June 2014, 362 ALS cases (59.

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