Publications by authors named "Andrea Montiel-Armendariz"
Article Synopsis
- BCAP (B cell adapter for PI 3-kinase) plays a critical role in B cell signaling, particularly in response to viral particles, but its specific function in antibody production was unclear.
- Research shows that deleting BCAP in B cells reduces their ability to respond to specific antigens by impairing the process of endocytosis through the B cell receptor (BCR).
- BCAP is essential for organizing actin around antigens for effective endocytosis and processing, which is crucial for presenting these antigens to T cells and facilitating B cell activation.
Emerging studies have highlighted the importance of tissue-resident B cells in the lungs, for protective immunity against respiratory viruses. However, the mechanisms controlling generation and maintenance of such tissue-resident B cells at respiratory sites remain obscure. We have previously shown that αv integrins limit B cell responses to antigens containing Toll-like receptor ligands, and that deletion of B cell αv integrins, in mice, enhances germinal center (GC)-derived long-lived B cell responses after systemic immunization with viral antigens.
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