COX-2 plays a role in angiogenic DBA(+) uNK cell subsets activation and pregnancy protection in LPS-exposed mice.

Introduction: Although uterine Natural Killer (uNK) cells have cytoplasmic granules rich in perforin and granzymes, these cells do not degranulate in normal pregnancy. DBA lectin(+) uNK cells produce angiogenic factors which stimulate remodeling of uterine arterioles to increase blood flow within the growing feto-placental unit. We sought to investigate the importance of COX-2 on mouse pregnancy inoculated with Gram-negative bacteria Lipopolysaccharide (LPS) by treating with a selective COX-2 inhibitor (nimesulide).

The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts.

Introduction: Follistatin-like-1 (FSTL1) is a widely expressed secreted protein with diverse but poorly understood functions. Originally described as a pro-inflammatory molecule, it has recently been reported to play a role in signaling pathways that regulate development and homeostasis. Distinctively, FSTL1 harbors within its 3'-UTR the sequence encoding microRNA-198 (miR-198), shown to be inversely regulated relative to FSTL1 expression and to exhibit opposite actions on cellular processes such as cell migration.

Prevalence of anxiety symptoms and depression in the third gestational trimester.

Objective: To determine the prevalence of anxiety and gestational depression and to determine the risk factors associated to its development.

Method: Pregnant women during their third quarter of pregnancy were invited to participate to the study, and they signed an informed consent form. After that, they filled in a general assessment questionnaire in which socio-economical and obstetrical characteristics together with general health conditions and behaviors harmful for the pregnancy were evaluated.