Publications by authors named "Andrea Milanesi"

Article Synopsis
  • Ionotropic gelation is an eco-friendly and cost-effective method for microencapsulation, but is often ineffective for highly soluble compounds due to material loss through diffusion.
  • Researchers improved the encapsulation efficiency of Thymus vulgaris L. extract in alginate microparticles by optimizing the ratio of thyme extract to alginate and adding co-carrier excipients.
  • The resulting microparticles exhibited a high encapsulation efficiency of 70.43%, a size of 1096 μm, and released the thyme extract completely within one hour, demonstrating the effectiveness of combining alginate and chitosan.
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Spray congealing technique was exploited to produce solid lipid microparticles (SLMp) loaded with a highly water-soluble drug (metoclopramide hydrochloride) dissolved in the aqueous phase of a water in oil (W/O) emulsion. The use of an emulsion as starting material for a spray congealing treatment is not so frequent. Moreover, for this application, a W/O emulsion with a drug dissolved in water is a totally novel path.

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The use of design space (DS) is a key milestone in the quality by design (QbD) of pharmaceutical processes. It should be considered from early laboratory development to industrial production, in order to support scientists with making decisions at each step of the product's development life. Presently, there are no available data or methodologies for developing models for the implementation of design space (DS) on laboratory-scale spray dryers.

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Sericin is a protein extracted from silk cocoons. Over the last decade, this wastewater product of the textile industry has shown many interesting biological properties. This protein is widely used in the cosmetic and biomedical fields.

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