Publications by authors named "Andrea Mattiello"
co-evolving with the CAG-repeat tract - modulates Huntington's disease phenotypes.
Mol Ther Nucleic Acids
September 2024
Article Synopsis
- Circular RNA (circRNA) is important for brain development and disorders, especially in Huntington's disease (HD).
- Researchers found a specific circRNA from the HD gene, which is most common in the brain and changes with the size of a DNA repeat in people and mice with HD.
- Although this circRNA doesn’t seem to make proteins in adult mouse brains, it might help regulate protein production and improve some problems caused by HD in brain cells.