Superficial and Deep Capillary Plexuses: Potential Biomarkers of Focal Retinal Defects in Eyes Affected by Macular Idiopatic Epiretinal Membranes? A Pilot Study.

Inner macular layers are the most involved in the retinal distortion caused by idiopathic epiretinal membrane (iERM). They represent the anatomical structures in which the superficial (SCP) and deep (DCP) capillary plexus are embedded. We quantified flow signal (FS) in these capillary plexuses using Swept Source OCT angiography to identify possible markers for postoperative outcome.

A Novel Autosomal Recessive Variant of the Gene Causing Enhanced S-Cone Syndrome: A Morpho-Functional Analysis of Two Unrelated Pediatric Patients.

Enhanced S-cone syndrome (ESCS) is a rare autosomal recessive retinal degeneration mainly associated with pathogenic variations in the gene. Only a few pathogenic variations in the gene associated with ESCS have been reported to date. Here, we describe the clinical and genetic findings of two unrelated pediatric patients with a novel frameshift homozygous variant in the gene.

Genetics of Inherited Retinal Diseases in Understudied Ethnic Groups in Italian Hospitals.

Describing the clinical and genetic features of an ethnically heterogeneous group of (inherited retinal diseases) IRD patients from different underrepresented countries, referring to specialized Italian Hospitals, and expanding the epidemiological spectrum of the IRD in understudied populations. The patients' phenotypes underwent were characterized by exhaustive ophthalmological examinations, including morpho-functional testing. Genetic testing was performed using next-generation sequencing (NGS) and gene sequencing panels targeting a specific set of genes, Sanger sequencing and-when necessary-multiplex ligation-dependent probe amplification (MLPA) to better identify the genotype.

Blue Cone Monochromatism with Foveal Hypoplasia Caused by the Concomitant Effect of Variants in and Genes.

Blue cone monochromatism (BCM) is an X-linked recessive cone dysfunction disorder caused by mutations in the gene cluster, encoding long (L)- and middle (M)-wavelength-sensitive cone opsins. Here, we report on the unusual clinical presentation of BCM caused by a novel mutation in the gene in a young man. We describe in detail the phenotype of the proband, and the subclinical morpho-functional anomalies shown by his carrier mother.

Dexamethasone Intravitreal Implant (Ozurdex) in Paediatric Patients with Non-infectious Intermediate Uveitis and Related Cystoid Macular Oedema: Evaluation of Macular Morphology and Function with Six-month Follow-up; a Deeper Role of MfERG?

Purpose: To evaluate the efficacy of Ozurdex implant by analyzing macular morphology and function in pediatric uveitis and related cystoid macular edema (CMO).

Methods: Main outcomes were visual acuity, mfERG and photopic ERG response, and central macular thickness. Mean values recorded at each time-point were compared to baseline and correlations between functional and anatomical parameters were evaluated.

Microperimetric retinal changes in myopic choroidal neovascularization treated with intravitreal ranibizumab.

Purpose: The purpose of this study was to report functional and morphologic retinal changes after intravitreal injections of 0.5 mg ranibizumab in patients with myopic neovascular membrane (choroidal neovascularization).

Methods: This is a case review of 11 consecutive patients with myopic choroidal neovascularization who received intravitreal injections of ranibizumab at monthly intervals.

Fellow eye findings of highly myopic subjects operated for retinal detachment associated with a macular hole.

Purpose: To identity anatomic risk factors involved in the onset of retinal complications causing decrease of visual acuity (VA) in the fellow eyes of highly myopic patients operated for retinal detachment with macular hole (RDMH).

Design: Cohort study.

Participants: Ninety-eight patients (mean age, 51.

Assessment of macular function by focal electroretinogram and pattern electroretinogram before and after epimacular membrane surgery.

Purpose: To evaluate macular function before and after surgical peeling of idiopathic epimacular membrane (EMM).

Methods: Logarithm of the minimal angle of resolution visual acuity and results of focal (central 9 x 9 degrees) electroretinogram (fERG), pattern electroretinogram (pERG), and optical coherence tomography (OCT) assessment of macular volume were evaluated for 22 eyes of 22 patients (mean age +/- SD, 63.20 +/- 10.

Posterior vitreous detachment and retinal detachment after cataract surgery.

Objective: To evaluate possible changes of vitreous status in emmetropic eyes after uneventful phacoemulsification surgery, and possible related complications such as the onset of retinal detachment (RD).

Design: Retrospective case series.

Participants: Four hundred fifty-three emmetropic eyes from 453 patients (mean age, 62.

Prevalence of asymptomatic macular holes in highly myopic eyes.

Objective: To evaluate the presence of macular holes (MHs) in very highly myopic eyes in the absence of visual symptoms.

Design: Retrospective case series.

Participants: Three hundred eighty-three eyes from 383 patients (mean age, 51.

Retinal detachment associated with macular hole in high myopia: using the vitreous anatomy to optimize the surgical approach.

Purpose: To evaluate the efficacy of different surgical strategies on the postoperative outcomes of retinal detachments (RDs) associated with macular holes (MHs) in high myopia.

Design: Prospective, noncomparative case series.

Participants: The study included 120 phakic, highly myopic eyes (mean degree of myopia, -22.