Publications by authors named "Andrea Margari"
Pharmaceutics
August 2022
Article Synopsis
- - The study focused on developing citicoline-loaded solid lipid nanoparticles (CIT-SLNs) to improve the treatment of Parkinson's disease due to the drug's positive effects on neurodegenerative conditions.
- - CIT-SLNs were created using Gelucire 50/13 as a lipid matrix, and various analyses (FT-IR, DSC, and XRPD) confirmed their solid-state properties, including a nano size and high drug entrapment.
- - Results showed that CIT-SLNs significantly protected dopaminergic cells from the neurotoxin 6-hydroxydopamine, improving cell viability and maintaining normal cell structure, suggesting they offer better protection than free citicoline.
