DNA methylation profile of genes related to immune response in generalized periodontitis.

Background And Objective: Epigenetic events, as the DNA methylation, may be related to development of inflammatory diseases. Due to the important role of host's response in the pathogenesis of periodontitis, the purpose of the present study was to investigate the methylation profile of genes related to immune response in gingival tissues from patients with generalized periodontitis (GP) compared to healthy individuals.

Methods: Gingival tissues were collected from 20 individuals with GP and 20 healthy individuals.