Publications by authors named "Andrea M C Ventura"
Article Synopsis
- Critically ill pediatric patients often face fluid accumulation (FA) due to administered fluids, which can lead to severe health complications and worsen outcomes.
- A systematic review and meta-analysis of 120 studies involving 44,682 children showed that FA significantly increased the risks of mortality, acute kidney injury, prolonged mechanical ventilation, and longer ICU stays.
- The findings suggest that careful monitoring and management of fluid levels in these patients is crucial to improve their overall health outcomes.
Haemodynamic support for paediatric septic shock: a global perspective.
Lancet Child Adolesc Health
August 2023
Article Synopsis
- Septic shock significantly affects children globally, leading to high hospitalisation and mortality rates, prompting the paediatric Surviving Sepsis Campaign to update guidelines in 2020 based on existing evidence.
- Recent trials from low and middle-income countries (LMICs) have provided new insights into effective treatment options, such as fluid management and vasoactive infusions.
- This viewpoint highlights the need for improved sepsis care in LMICs by addressing early recognition of septic shock, fluid resuscitation, and individualised treatment approaches using accessible monitoring tools.
Article Synopsis
- The COVID-19 pandemic is a serious global health crisis, but most children experience mild symptoms from the virus.
- A rare and dangerous complication in kids is Multisystem Inflammatory Syndrome in Children (MIS-C), which can be life-threatening.
- This text discusses a specific case where a child with COVID-19 had appendicitis, with the virus also found in the appendix tissue.
Objective: To report the prevalence and outcomes of sepsis in children admitted to public and private hospitals.
Methods: Post hoc analysis of the Latin American Pediatric Sepsis Study (LAPSES) data, a cohort study that analyzed the prevalence and outcomes of sepsis in critically ill children with sepsis on admission at 21 pediatric intensive care units in five Latin American countries.
Results: Of the 464 sepsis patients, 369 (79.
Background: COVID-19 in children is usually mild or asymptomatic, but severe and fatal paediatric cases have been described. The pathology of COVID-19 in children is not known; the proposed pathogenesis for severe cases includes immune-mediated mechanisms or the direct effect of SARS-CoV-2 on tissues. We describe the autopsy findings in five cases of paediatric COVID-19 and provide mechanistic insight into the mechanisms involved in the pathogenesis of the disease.
View Article and Find Full Text PDFObjectives: To report the prevalence of sepsis within the first 24 hours at admission and the PICU sepsis-related mortality among critically ill children admitted to PICU in South America.
Design: A prospective multicenter cohort study.
Setting: Twenty-one PICU, located in five South America countries.
Objectives: The primary outcome was to compare the effects of dopamine or epinephrine in severe sepsis on 28-day mortality; secondary outcomes were the rate of healthcare-associated infection, the need for other vasoactive drugs, and the multiple organ dysfunction score.
Design: Double-blind, prospective, randomized controlled trial from February 1, 2009, to July 31, 2013.
Setting: PICU, Hospital Universitário da Universidade de São Paulo, Brazil.
Objective: Nutrition therapy protocols seek to correlate current scientific knowledge with clinical practice by converting evidence-based efficacy data into clinical effectiveness. Implementing nutrition therapy protocols should be justified by their impact on clinical outcomes. Thus, our objective was to analyze studies that verified the effect of implementing protocols for enteral nutrition (EN) in critically ill patients who are mechanically ventilated.
View Article and Find Full Text PDFObjective: The objective of this study was to evaluate the ratio of dead space to tidal volume (VD/VT) as a predictor of extubation failure of children from mechanical ventilation.
Methods: From September 2001 to January 2003 we studied a cohort consisting of all children (1 day-15 years) submitted to mechanical ventilation at a pediatric intensive care unit who were extubated and for whom pre-extubation ventilometry data were available, including the VD/VT ratio. Extubation success was defined as no need for any type of ventilatory support, invasive or otherwise, within 48 hours.
Objective: To report a case of airway disruption in a child victim of blunt thoracic trauma due to falling off a sink.
Description: Descriptive case report. A 34-month old boy victim of thoracic trauma was seen at the pediatric intensive care unit of a university hospital.