Thermoradiotherapy Optimization Strategies Accounting for Hyperthermia Delivery Uncertainties.

Purpose: The combined effect of hyperthermia and radiation therapy can be quantified by an enhanced equivalent radiation dose (EQD). Uncertainties in hyperthermia treatment planning and adjustments during treatment can impact achieved EQD. We developed and compared strategies for EQD optimization of radiation therapy plans, focusing on robustness against common adjustments.