Treatment with BKI-1748 after systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection.

Drug development for congenital toxoplasmosis is challenging since first-line therapy has a high rate of adverse effects and exhibits suboptimal efficacy. Bumped kinase inhibitors (BKIs), targeting protein kinases with small gatekeeper residues, have been found to be effective against . The efficacy of BKI-1748 administered later than 2 days post-infection (p.

Short-term culture adaptation of Toxoplasma gondii archetypal II and III field isolates affects cystogenic capabilities and modifies virulence in mice.

Most Toxoplasma gondii research has been carried out using strains maintained in the laboratory for long periods of time. Long-term passage in mice or cell culture influences T. gondii phenotypic traits such as the capability to produce oocysts in cats and virulence in mice.

Archetypal type II and III oocysts induce different immune responses and clinical outcomes in experimentally infected piglets.

Livestock animals, such as swine, are an important source of in the human population. Currently, there is limited knowledge regarding the potential influence that the genotype might exert on establishing infection in swine. Herein, we investigated the role of 2 isolates, type II and III, representative of the genotypes circulating in Europe, in the immune responses and infection dynamics in piglets.