Sequelae of Fetal Infection in a Non-human Primate Model of Listeriosis.

(Lm) is a common environmental bacterium that thrives on vegetation and soil matter, but can infect humans if contaminated food products are ingested, resulting in severe disease in immunosuppressed populations, including pregnant women and newborns. To better understand how the unique immunological milieu of pregnancy increases susceptibility to infection, we study listeriosis in cynomolgus macaques, a non-human primate that closely resembles humans in placentation and in the physiology, and immunology of pregnancy. Non-human primates are naturally susceptible to Lm infection, and spontaneous abortions due to listeriosis are known to occur in outdoor macaque colonies, making them ideal models to understand the disease pathogenesis and host-pathogen relationship of listeriosis.

A new locus (GLC1H) for adult-onset primary open-angle glaucoma maps to the 2p15-p16 region.

Objective: To map new genetic loci for adult-onset primary open-angle glaucoma (POAG) by using families previously unlinked to GLC1A-GLC1F.

Methods: Initial genome scan and subsequent saturation mapping confirmed linkage to a locus on chromosome 2p15-p16. Forty-nine DNA samples from a single family with POAG with 113 individuals were used in this study.

Reproducibility of LASIK flap thickness using the Hansatome microkeratome.

Purpose: To evaluate the actual versus the expected thickness of laser in situ keratomileusis (LASIK) flaps and to determine the factors that affect flap thickness.

Setting: Centre For Sight, Queen Victoria Hospital, East Grinstead, United Kingdom.

Methods: A retrospective analysis of LASIK procedures in 757 consecutive eyes was done.