Publications by authors named "Andrea Heisey"
Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods.
View Article and Find Full Text PDFObjectives: The objective of this study is to evaluate the impact of therapeutic HIV vaccination on the HIV reservoir and assess the relationship of the viral reservoir with HIV-specific immune status and viral rebound kinetics.
Design: A retrospective analysis of ACTG A5197, a randomized, placebo-controlled trial of a therapeutic rAd5 HIV-1 gag vaccine.
Methods: Participants received vaccine/placebo at weeks 0, 4 and 26 prior to a 16-week analytic treatment interruption (ATI) at week 38.
Article Synopsis
- The study investigates whether allogeneic hematopoietic stem cell transplantation (HSCT) can lead to long-term HIV-1 remission in two patients who had undetectable levels of the virus.
- Both patients showed no detectable HIV-1 in their blood and rectal tissue for several weeks after stopping antiretroviral therapy, but eventually experienced a rebound of the virus with acute symptoms.
- Findings suggest that while HSCT may decrease HIV reservoirs, persistent reservoirs can lead to viral rebound, indicating that further research is needed to understand the long-term effects and viability of HSCT for sustained HIV-1 remission.
Objectives: To evaluate the relationship between incomplete antiretroviral therapy (ART) adherence and levels of residual HIV-1 viremia.
Design: Medication adherence and residual viremia less than 50 copies/ml were quantified in participants of a cohort of homeless and marginally housed individuals with HIV/AIDS.
Methods: Participants had at least 6 months of virologic suppression of less than 50 copies/ml and were in the adherence monitoring cohort with monthly unannounced pill counts.