Modulation of caspase activation by Toxoplasma gondii.

Apoptosis plays crucial roles for the outcome of infection with various infectious agents. The host's apoptotic program may be modulated after infection in order to combat the pathogen or to restrict the immune response. In addition, distinct microorganisms alter the apoptotic program of the host in order to meet the requirements for their further distribution.

Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication.

Poly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.